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위식도역류질환의 임상 특징과 Helicobacter pylori 감염과의 상관관계

Other Titles
 Clinical Characteristics of Gastroesophageal Reflux Diseases and Association with Helicobacter pylori Infection 
 김병창  ;  윤영훈  ;  정현수  ;  정재복  ;  전재윤  ;  이상인  ;  이용찬 
 Korean Journal of Gastroenterology, Vol.47(5) : 363-369, 2006 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Aged ; Barrett Esophagus/diagnosis ; Barrett Esophagus/drug therapy ; Barrett Esophagus/microbiology ; Female ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/microbiology* ; Helicobacter Infections/complications* ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter pylori* ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Prevalence
Gastroesophageal reflux disease ; Erosoive reflux esophagitis ; Non-erosive reflux disease ; Helicobacter pylori ; Barrett`s esophagus ; 위식도역류질환 ; 식도염 ; 바렛 식도
Background/Aims: The prevalence of gastroesophageal reflux disease (GERD) in Korea was believed to be low until now. Korea is now believed to be on the evolving stage of GERD in its' prevalence. The aims of this study were to evaluate the epidemiologic and clinicopathologic characteristics among the subgroups of GERD i.e. non-erosive GERD (NERD), erosive GERD (ERD) and Barrett's esophagus (BE), and the role of Helicobacter pylori (H. pylori) infection in the pathogenesis of GERD. Methods: A total of 253 patients with typical symptoms of GERD who underwent EGD were enrolled from October 2002 to January 2004. Patients were grouped as NERD, ERD or BE based on the symptoms and endoscopic findings. BE was histologically confirmed if necessary. Various clinical parameters including the status of H. pylori infection were analyzed. Results: Among 253 patients, 106 patients were classified as NERD while 116 and 31 patients were classified as ERD and BE group respectively. BE and ERD group showed no gender predilection while NERD showed female preponderance (2.31:1, p<0.05). NERD group were younger (49.57 y.o.) than BE (57.87 y.o.) and ERD (52.30 y.o.) group. About three quarters of the patients of erosive esophagitis were LA-A (74.2%) grade. This suggests the mild nature of erosive esophagitis in Korea. ERD showed significantly higher BMI (kg/m2) compared to NERD (p<0.05). Hiatal hernia was frequently associated with BE and ERD (p<0.05), but less frequently in NERD. Overall H. pylori positivity among GERD was significantly lower than the age and gender matched control group (p<0.05). Conclusions: Subgroups of GERD in Korea showed different epidemiologic and clinical characteristics. Lower rate of H. pylori infection among GERD group may reflect the protective role of H. pylori infection regarding GERD prevalence in Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang In(이상인)
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Chon, Chae Yoon(전재윤)
Chung, Jae Bock(정재복)
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