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건강한 성인남녀의 혈청 γ-glutamyltransferase (γ-GT)와 혈청 페리틴과의 연관성
DC Field | Value | Language |
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dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이혜리 | - |
dc.date.accessioned | 2015-06-10T13:02:18Z | - |
dc.date.available | 2015-06-10T13:02:18Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 2005-6443 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110894 | - |
dc.description.abstract | Background : Serum γ-GT is one of the biliary enzymes with the only enzymatic activity capable of cleaving extracellular glutathione, thus originating precursor amino acids for the intracellular resynthesis of glutathione. Several population-based studies have shown a strong cross-sectional association between serum γ-GT concentration and cardiovascular risk factors. And prospective studies showed that serum γ-GT concentration had a prognostic impact on cardiovascular mortality. But, the mechanism by which γ-GT is associated with cardiovascular disease is not elucidated. We hypothesized that there was an association between serum γ-GT and ferritin, a marker of oxidative stress. In this study, we investigated the relationship between serum γ-GT and serum ferritin. Methods : By reviewing the medical records of 288 healthy adults, we determined the serum levels of γ-GT and ferritin according to age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL-cholesterol, fasting blood sugar, hs-CRP, serum ferritin, AST, ALT, uric acid and smoking history. We studied the relationship between the variables by Pearson correlation coefficients and multiple stepwise regression analysis. Mean values of serum γ-GT according to the smoking history were compared using t-test. Results : Serum γ-GT correlated positively with serum ferritin (r=0.42; P<0.001). BMI, triglycerides, total cholesterol, fasting blood sugar, AST and ALT also showed statistically significant correlation. Smokers showed significantly higher serum γ-GT. Serum γ-GT correlated with serum ferritin, ALT, current smoking and triglycerides by multiple stepwise regression analysis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한가정의학회 | - |
dc.relation.isPartOf | Journal of the Korean Academy of Family Medicine (가정의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 건강한 성인남녀의 혈청 γ-glutamyltransferase (γ-GT)와 혈청 페리틴과의 연관성 | - |
dc.title.alternative | Relationship between Serum γ-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | 김정하 | - |
dc.contributor.googleauthor | 이혜리 | - |
dc.contributor.googleauthor | 한아름 | - |
dc.contributor.googleauthor | 임지애 | - |
dc.contributor.googleauthor | 이덕철 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A03310 | - |
dc.relation.journalcode | J03700 | - |
dc.identifier.eissn | 2092-6715 | - |
dc.subject.keyword | gamma-GT | - |
dc.subject.keyword | γ-GT | - |
dc.subject.keyword | ferritin | - |
dc.subject.keyword | oxidative stress | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Hye Ree | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Lee, Hye Ree | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 645 | - |
dc.citation.endPage | 651 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Academy of Family Medicine (가정의학회지), Vol.27(8) : 645-651, 2006 | - |
dc.identifier.rimsid | 54934 | - |
dc.type.rims | ART | - |
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