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Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1)

Authors
 Hye-Sun Seo  ;  Tae Soo Kang  ;  Sungha Park  ;  Eui Young Choi  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Jongwon Ha  ;  Se-Joong Rim  ;  Namsik Chung 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.112(2) : 171-177, 2006 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2006
MeSH
Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Blood Flow Velocity ; Blood Pressure/physiology* ; Blood Pressure Monitoring, Ambulatory ; Coronary Vessels/diagnostic imaging ; Diastole/physiology ; Echocardiography, Doppler ; Female ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Systole/physiology ; Ventricular Dysfunction, Left/physiopathology* ; Ventricular Remodeling/physiology*
Keywords
Non-dippers ; Ambulatory blood pressure ; Cardiac remodeling ; LV dysfunction
Abstract
BACKGROUND: Non-dippers are known to carry a high risk of cardiovascular complications due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with adverse cardiac remodeling and left ventricular (LV) dysfunction in treated hypertensive patients. MATERIALS AND METHODS: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The patients were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10% during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E') and LV systolic function was assessed by measuring systolic tissue velocity (S'), longitudinal systolic strain and strain rate. RESULTS: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E') was lower and E/E' was higher in non-dippers suggestive of diastolic dysfunction. Systolic tissue velocity (S'), systolic strain and strain rate were significantly lower in non-dippers suggestive of systolic dysfunction. The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E' (beta=-0.203, P=0.002), E/E' (beta=0.354, P<0.001), S' (beta=-0.231, P=0.002), strain (beta=-0.162, P=0.040) and strain rate (beta=-0.186, P=0.015). CONCLUSIONS: This study showed the non-dippers in treated hypertensive patients were associated with adverse cardiac remodeling and early LV dysfunction. Further studies to demonstrate the long term prognostic significance of this finding is warranted.
Full Text
http://www.sciencedirect.com/science/article/pii/S016752730501171X
DOI
10.1016/j.ijcard.2005.08.038
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110890
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