2 190

Cited 9 times in

Intravenous glucose–insulin–potassium during off-pump coronary artery bypass surgery does not reduce myocardial injury

 Y. H. Shim  ;  T. D. Kweon  ;  J. H. Lee  ;  S. B. Nam  ;  Y. L. Kwak 
 Acta Anaesthesiologica Scandinavica, Vol.50(8) : 954-961, 2006 
Journal Title
 Acta Anaesthesiologica Scandinavica 
Issue Date
Aged ; Blood Glucose/analysis ; Cardioplegic Solutions/administration & dosage* ; Coronary Artery Bypass, Off-Pump* ; Creatine Kinase, MB Form/blood ; Double-Blind Method ; Female ; Glucose/administration & dosage* ; Heart/drug effects ; Humans ; Infusions, Intravenous ; Insulin/administration & dosage ; Intraoperative Care ; Male ; Middle Aged ; Myocardial Ischemia/prevention & control* ; Potassium/administration & dosage ; Prospective Studies ; Troponin T/blood
cardiac enzyme ; cardiac performance ; coronary artery bypass surgery ; glucose–insulin–potassium ; myocardial damage ; off‐pump
Background:  This randomized, double-blind, placebo-controlled study was designed to determine whether an intra-operative, intravenous infusion of glucose–insulin–potassium (GIK) could be helpful in the prevention of myocardial ischemia and in the maintenance of intra-operative cardiac performance in patients undergoing off-pump coronary artery bypass (OP-CAB) surgery. Methods:  Eighty two adults undergoing elective OP-CAB surgery were randomly divided into two groups that received intravenously either 5% dextrose in water or GIK (50% dextrose in 500 ml of water; regular insulin, 125 IU; potassium, 80 mmol) at 0.75 ml/kg/h immediately before the induction of anesthesia to the end of surgery. To evaluate myocardial damage, creatine kinase MB and troponin T were measured before surgery, immediately after arrival in the intensive care unit and on the first post-operative day. To assess cardiac performance, hemodynamic data were obtained before and after the induction of anesthesia, before and after the bypass graft and after sternal closure. Blood glucose was measured at the same time. Results:  There was no significant difference in cardiac enzymes, hemodynamic parameters and blood glucose between the two groups. The use of vasoactive, inotropic and/or anti-arrhythmic agents, insulin and supplemental glucose was not significantly different between the groups. Conclusion:  The results suggest that the intravenous administration of GIK during OP-CAB surgery neither reduces myocardial damage nor improves intra-operative cardiac performance in patients without contractile dysfunction.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kweon, Tae Dong(권태동) ORCID logo https://orcid.org/0000-0002-5451-1856
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Lee, Jong Wha(이종화)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.