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Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy

Authors
 Phil Hyu Lee  ;  Seung Hyeon Yeo  ;  Hyun Joon Kim  ;  Hyo Young Youm 
Citation
 MOVEMENT DISORDERS, Vol.21(11) : 1975-1977, 2006 
Journal Title
MOVEMENT DISORDERS
ISSN
 0885-3185 
Issue Date
2006
MeSH
3-Iodobenzylguanidine/chemistry* ; Aged ; Female ; Heart/diagnostic imaging ; Heart/drug effects ; Humans ; Male ; Middle Aged ; Multiple System Atrophy/diagnostic imaging ; Multiple System Atrophy/physiopathology* ; Odorants* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/physiopathology* ; Radionuclide Imaging ; Radiopharmaceuticals/chemistry* ; Smell/drug effects ; Smell/physiology* ; Statistics as Topic
Keywords
olfactory function ; cardiac MIBG ; Parkinson's disease
Abstract
We investigated an association between olfaction and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.21083/abstract
DOI
10.1002/mds.21083
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110813
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