Cardiac 123I-MIBG scintigraphy in patients with drug induced parkinsonism

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Citation: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.77(3) : 372-374, 2006

MeSH: Adult ; Aged ; Antipsychotic Agents/toxicity* ; Calcium Channel Blockers/toxicity* ; Dopamine Antagonists/toxicity* ; Female ; Heart/innervation ; Heart Diseases/chemically induced* ; Heart Diseases/diagnostic imaging ; Humans ; Male ; Mediastinum/diagnostic imaging ; Middle Aged ; Parkinsonian Disorders/chemically induced* ; Parkinsonian Disorders/diagnostic imaging ; Prognosis ; Prospective Studies ; Sympathetic Nervous System/diagnostic imaging ; Sympathetic Nervous System/drug effects ; Technetium Tc 99m Sestamibi* ; Tomography, Emission-Computed, Single-Photon*

Abstract: Cardiac sympathetic dysfunction was investigated using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug induced parkinsonism (DIP). The mean heart to mediastinum ratio was significantly greater in patients with DIP than in those with Parkinson's disease (mean (SD): 2.07 (0.39) v 1.28 (0.15), p<0.001). MIBG uptake was not different between the DIP patients and controls. Two DIP patients whose MIBG uptake was significantly reduced showed persistent parkinsonism and responded dramatically to levodopa.