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Factors affecting long-term clinical outcomes of endoscopic mucosal resection of early gastric cancer

 Jong Chan Youn  ;  Young Hoon Youn  ;  Tae II Kim  ;  Seung Woo Park  ;  Se Joon Lee Si Young Song  ;  Jae Bock Chung  ;  Yong Chan Lee JC Youn  ;  YH Youn 
 HEPATO-GASTROENTEROLOGY, Vol.53(70) : 643-647, 2006 
Journal Title
Issue Date
Aged ; Carcinoma/pathology ; Carcinoma/surgery* ; Endoscopy, Gastrointestinal/methods* ; Female ; Gastric Mucosa/surgery* ; Humans ; Male ; Middle Aged ; Risk Factors ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Time Factors ; Treatment Outcome
BACKGROUND/AIMS: Endoscopic mucosal resection (EMR) has been widely accepted as a treatment option for early gastric cancer (EGC) in selected cases. The purposes of this study were to evaluate the long-term outcomes and the factors affecting the clinical outcomes, of EMR performed in EGC.
METHODOLOGY: Between April 1996 and March 2005, 147 patients have undergone EMR to treat EGC at Yonsei University Medical Center, Seoul, Korea. We assessed the clinical outcomes of the EMR for EGC in a long-term follow-up period. We also reviewed the medical records of the patients including demographic data, endoscopic characteristics of the lesion and histopathologic findings.
RESULTS: The histopathologic evaluations after the EMR treatment showed that overall complete resection rate was 84.6% (126/149) while complete resec tion rate of 93.5% was achieved in mucosal cancers (115/123). The success of complete resection was significantly affected by endoscopic gross type (depressed lesion), the degree of differentiation, and the depth of invasion, independently. There were only 5 cases of local recurrence during the follow-up periods, and the recurred or incompletely resected lesions were successfully treated by salvage operation or endoscopic retreatment. There was no disease-related or treatment-related mortality during the follow-up period.
CONCLUSIONS: EMR is a good and safe curative treatment option with feasible clinical outcomes in patients with EGC. It must be emphasized that a proper selection of candidates is mandatory to improve the clinical outcome of EMR in EGC.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Lee, Se Joon(이세준) ORCID logo https://orcid.org/0000-0002-2695-2670
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Chung, Jae Bock(정재복)
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