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Comparison of Body Fat Composition and Serum Adiponectin Levels in Diabetic Obesity and Non-diabetic Obesity

Authors
 Chulsik Kim  ;  Jina Park  ;  Jongsuk Park  ;  Eunseok Kang  ;  Chulwoo Ahn  ;  Bongsoo Cha  ;  Sungkil Lim  ;  Kyungrae Kim  ;  Hyunchul Lee 
Citation
 OBESITY, Vol.14(7) : 1164-1171, 2006 
Journal Title
 OBESITY 
ISSN
 1930-7381 
Issue Date
2006
MeSH
Adiponectin/blood* ; Adipose Tissue/anatomy & histology ; Adipose Tissue/metabolism* ; Adult ; Blood Glucose/metabolism ; Body Composition/physiology* ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism* ; Female ; Humans ; Insulin/metabolism ; Insulin Resistance ; Male ; Muscle, Skeletal/metabolism ; Obesity/blood ; Obesity/metabolism* ; Tomography, X-Ray Computed/methods
Keywords
visceral fat ; subcutaneous fat ; low‐density muscle ; insulin resistance ; diabetes mellitus
Abstract
OBJECTIVE: Clinical aspects of diabetes and obesity are somewhat different, even at similar levels of insulin resistance. The purpose of this study was to determine differences in body fat distribution and serum adiponectin concentrations in diabetic and non-diabetic obese participants. We were also interested in identifying the characteristics of insulin resistance in these two groups, particularly from the standpoint of adiponectin. RESEARCH METHODS AND PROCEDURES: Adiponectin concentrations of 112 type 2 diabetic obese participants and 124 non-diabetic obese participants were determined. Abdominal adipose tissue areas and midthigh skeletal muscle areas were measured by computed tomography. A homeostasis model assessment of the insulin resistance score was calculated to assess insulin sensitivity. The relationships among serum adiponectin, body fat distribution, and clinical characteristics were also analyzed. RESULTS: Both abdominal subcutaneous and visceral fat areas were higher in the non-diabetic obese group, whereas midthigh low-density muscle area was higher in the diabetic obese group. The homeostasis model assessment of the insulin resistance score was similar between groups, whereas serum adiponectin was lower in the diabetic obese group. Abdominal visceral fat (beta = -0.381, p = 0.012) was a more important predictor of adiponectin concentration than low-density muscle (beta = -0.218, p = 0.026) in cases of non-diabetic obesity, whereas low-density muscle (beta = -0.413, p = 0.013) was a better predictor of adiponectin level than abdominal visceral fat (beta = - 0.228, p = 0.044) in diabetic obese patients. DISCUSSION: Therefore, factors involved in pathophysiology, including different serum adiponectin levels and body fat distributions, are believed to be responsible for differences in clinical characteristics, even at similar levels of insulin resistance in both diseases.
Full Text
http://onlinelibrary.wiley.com/doi/10.1038/oby.2006.133/abstract
DOI
10.1038/oby.2006.133
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110730
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