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골수형성이상증후군

Other Titles
 Myelodysplastic Syndrome 
Authors
 정준원  ;  민유홍 
Citation
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION , Vol.49(10) : 897-907, 2006 
Journal Title
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION 
ISSN
 1975-8456 
Issue Date
2006
Keywords
Myelodysplastic syndrome ; Pathophysiology ; Diagnosis ; Classification ; Treatment
Abstract
Myelodysplastic syndrome (MDS) is a clonal stem cell disorder characterized by ineffective hematopoiesis, multilineage dysplasia, peripheral cytopenias with normocellular or hypercellular marrow, and susceptibility to leukemic transformation. MDS represents a heterogenous group of disorders with a wide spectrum of clinical, morphological, biologic, and genetic characteristics. MDS is classified according to the World Health Organization criteria and the International Prognostic Scoring System. Risk-adapted treatment strategies have been developed in consideration of the advanced age of patients and to improve the clinical course of the disease. The pathophysiology, cytogenetic/molecular profiles, clinical characteristics and treatment modalities according to the prognostic groups will be described. In the future, a combination of treatment modalities to increase gene reactivation and to take advantage of increased expression of target genes may be critical to improve clinical outcomes. Multiple pathways may be involved in the MDS phenotype, and combination therapies, including novel agents, may be required to make further progresses in the treatment of this disease.
Files in This Item:
T200601687.pdf Download
DOI
10.5124/jkma.2006.49.10.897
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110710
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