정상 임신 동안 모체 혈청의 High Sensitivity C-Reactive Protein의 변화

Abstract

Objective: The purpose of this study was to clarify the changes in maternal serum high sensitivity C- reactive protein (hsCRP) during normal human pregnancy. Method: A total of 202 normal pregnant women from September, 2004 to August, 2005 who received continuous prenatal care and underwent delivery at Severance Hospital were enrolled in the study. Gestational age ranged between 5 and 39 weeks. Subjects were divided into four groups (group I, 5-9 gestational weeks (GWks) [n=58]; group II, 15-20 GWks [n=63]; group III, 24-30 Gwks [n=34]; Group IV, 30-39 GWks [n=47]). The levels of hsCRP were measured in maternal serum. The hsCRP assay was used by Pureauto S CRP latex (DAIICHI, Tokyo, Japan). Result: The median (minimum-maximum) levels of hsCRP of each groups was 0.08 mg/dl (0.02-1.36 mg/dl), 0.15 mg/dl (0.04-2.03 mg/dl), 0.21 mg/dl (0.05-0.95 mg/dl), 0.23 mg/dl (0.04-0.81 mg/dl) in group I, II, III and IV, respectively. As gestational age increased, the median level of hsCRP increased. Gwks and hsCRP level showed a positive correlation tendency, but this correlation was statistically insignificant. Other parameters, such as maternal age (p=0.11), delivery weeks (p=0.08), delivery mode (p=0.98), birth weights (p=0.33), had no correlation with hsCRP. Conclusion: To our knowledge, this is the first report of change in serum hsCRP during normal human pregnancy. Reference value of hsCRP during pregnancy may be important for making clinical decisions in circumstances such as infection, glucose intolerance during pregnancy or preeclamsia