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60세 이상에서 발생하는 류마티스관절염의 임상 특성

Other Titles
 Clinical Characteristics of Late-onset Rheumatoid Arthritis 
 정세진  ;  길지훈  ;  최상태  ;  강은진  ;  이상원  ;  박민찬  ;  박용범  ;  이수곤 
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.13(4) : 291-298, 2006 
Journal Title
Journal of the Korean Rheumatism Association(대한류마티스학회지)
Issue Date
Late-onset rheumatoid arthritis ; Younger-onset rheumatoid arthritis
Objective: Late-onset rheumatoid arthritis (LORA) refereed as the subset of rheumatoid arthritis with age of onset over 60 years old, seems to differ from younger onset disease (YORA) by more equal sex distribution, a higher frequency of abrupt disease onset, more large joints involvement, more extraarticular manifestation, erythrocyte sedimentation test (ESR), and less rheumatoid factor (RF) positivity. We need data of LORA in Korea because of lack of data. Methods: Two hundred and forty-two patients were studied retrospectively. We compared the difference with clinical manifestation, disease activity markers, RF, ANA, and radiologic changes between LORA and YORA. Sums of ESR and C-reactive protein (CRP) during first year after diagnosis were calculated through area under curve. Radiologic joint damages were evaluated using modified Sharp score. Results: The gender ratio (female/male) was 1.54 in LORA and 6.43 in YORA (p<0.001). The duration of the diagnosis was longer in LORA than in YORA (25.2±27.0months, 18.5±22.2 months, p=0.048). Tender and swollen joint, and involvement of joints were not different in the groups. ESR, CRP, platelet, and RF were higher with LORA. Sums of ESR and CRP were higher in LORA than in YORA (403.7±252.2 mm/hr, 25.6±41.1 mg/dL vs 281.4±201.3, 12.0±15.0). There was no difference of modified Sharp score in both groups. Conclusion: The LORA has an equal gender ratio, longer morning stiffness and disease duration, and higher levels of RF, platelet, ESR, CRP, and summation of ESR and CRP, which suggests that LORA may have poorer prognosis than YORA.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Min Chan(박민찬) ORCID logo https://orcid.org/0000-0003-1189-7637
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
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