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Comparison of allergic indices in monosensitized and polysensitized patients with childhood asthma

Authors
 Kyung Won Kim  ;  Eun Ah Kim  ;  Byoung Chul Kwon  ;  Eun Soo Kim  ;  Tae Won Song  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.21(6) : 1012-1016, 2006 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2006
MeSH
Asthma/classification* ; Asthma/diagnosis* ; Child ; Female ; Health Status Indicators* ; Humans ; Hypersensitivity/classification* ; Hypersensitivity/diagnosis* ; Male ; Reproducibility of Results ; Sensitivity and Specificity ; Skin Tests/methods*
Keywords
Asthma ; Child ; Immunotherapy ; Immunoglobulin E
Abstract
Monosensitization differs both immunologically and clinically from polysensitization, and specific immunotherapy is more effective in patients sensitized only to a single pollen than in multiple-pollen sensitized patients. To further examine the differences between monosensitized and polysensitized allergies, allergic indices were examined in 68 monosensitized and 62 polysensitized patients with childhood asthma. Measurements included symptom scores, eosinophil counts, skin prick tests, serum total and specific IgE levels, and IL-10 levels, and were used to compare allergic indices between the two groups. Patients were followed for 18 months following immunotherapy to examine the effectiveness of the treatment. Symptom scores and total IgE levels were significantly higher in the polysensitized group than those in the monosensitized group (p<0.05). The levels of skin test response decreased significantly in both groups following immunotherapy. In the monosensitized group, symptom scores and specific IgE levels were significantly reduced after immunotherapy (p<0.05). In the polysensitized group, symptom scores were reduced after immunotherapy (p<0.05), but the degree of reduction was less than that of the monosensitized group (p<0.05). Moreover, in the polysensitized group, specific IgE levels after immunotherapy did not differ from that before immunotherapy. Serum IL-10 levels were not significantly increased after immunotherapy in either group. In conclusion, polysensitized patients tend to show higher allergic indices and immunotherapy might be less effective for these patients.
Files in This Item:
T200601562.pdf Download
DOI
10.3346/jkms.2006.21.6.1012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110570
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