1 148

Cited 0 times in

인공 장애물에 의한 심실세동의 동역학적 변화의 광학적 지도 분석

Other Titles
 The Effects of Obstacles on the Dynamics of Ventricular Fibrillation 
Authors
 정보영  ;  구본권  ;  서정철  ;  김일권  ;  황기철  ;  이문형  ;  김성순 
Citation
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학), Vol.3(3) : 286-294, 2006 
Journal Title
 Tissue Engineering and Regenerative Medicine  (조직공학과 재생의학) 
ISSN
 1738-2696 
Issue Date
2006
Abstract
The effects of artificial obstacles on the dynamics of ventricular fibrillation have been extensively investigated with an electrical mapping system. This study was performed to assess the influence of transmural obstacles on the dynamics of wavefronts and to determine whether obstacles can convert ventricular fibrillation to ventricular tachycardia by stabilizing wavefronts in fibrillating right ventricular tissues of pigs using an optical mapping system. The right ventricles of pigs(n=15) were excised and placed in a tissue perfusion system with the epicardium facing up. A hole of increasing size from 2 mm to 8 mm in diameter was created using a skin biopsy punch. Then, the other 8mm sized hole was made just beside the first hole. The changes of wavefront dynamics and the cycle length of optical action potential waves were investigated. In 14 among 20 obstacles of ten tissues, transient attachment of electrical activities along the rim of obstacles and transient rotation of wavefronts were observed. During baseline ventricular fibrillation, fibrillation cycle length was 118.5±24.7 msec and this was increased to 135.4±30.2 msec after 8mm hole, and to 159.4±47.7 msec after 2 holes(p=0.01). There was a positive correlation between the obstacle size and cycle length(r=0.43, p=0.007). In three tissues, conversion to ventricular tachycardia from ventricular fibrillation was observed after creation of two holes. Obstacles of proper size had anti-fibrillatory effects in tissues with ventricular fibrillation and this phenomenon was partly explained by the temporary attachment of wavefronts to the obstacles.
Full Text
http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=3118778
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김성순(Kim, Sung Soon)
이문형(Lee, Moon Hyoung) ORCID logo https://orcid.org/0000-0002-7268-0741
정보영(Joung, Bo Young) ORCID logo https://orcid.org/0000-0001-9036-7225
황기철(Hwang, Ki Chul)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110551
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse