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The Change of Ventricular Tachycardia by Cryoinjury on the Swine Right Ventricular Epicardium

 Boyoung Joung  ;  Zhengzhe Xu  ;  Ilkwon Kim  ;  Ki-Chul Hwang  ;  Namsik Chung  ;  Moonhyoung Lee  ;  Sungsoon Kim 
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학), Vol.3(3) : 344-351, 2006 
Journal Title
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학) 
Issue Date
Activation mapping ; arrhythmias ; ventricular tachycardia/fibrillation
This study was performed to assess the influence of the cryoinjury on the dynamics of wavefronts and to determine whether they can convert ventricular fibrillation(VF) to ventricular tachycardia(VT) in fibrillating right ventricular(RV) of swines using an optical mapping system. A cryoinjury with a diameter of 12 mm was created on the epicardium of perfused RV of swines(n=6) and optical mapping were taken from baseline until 10 min after the cryoinjury. Out of 35 cryoinjuries, the images were possible to be interpreted in 32. The optical action potential could not be observed in either the cryoinjury or peri-injury sites at 1 and 3 min, was observed in only the cryoinjury site at 5 min, and recovered in both sites at 10 min. The cycle length of the tachycardia was 135.9±23.6 msec at baseline, 176.2±79.3 msec at 1 min, 187.6±97.9 msec at 3 min, 185.5±19.2 msec at 5 min, and 152.1±64.1 msec at 10 min. The cycle lengths at 1, 3, and 5 min after the cryoinjury were significantly more prolonged than that atbaseline (p=0.001, p=0.006, p=0.016). After the cryoinjury, the VF changed to VT in 9(28.0%), and terminated in 2(6.3%). These changes were observed mainly within 5 min after cryoinjury. The cryoinjury had anti-fibrillatory effects on the tissue with VF. This phenomenon was related to a decreasing mass and stabilizing wavefronts
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1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soon(김성순)
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Chung, Nam Sik(정남식)
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
Hwang, Ki Chul(황기철)
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