Tumors of the minor papilla of duodenum are so rare that only a few cases have been reported, with the exception of neuroendocrine tumor, gangliocytic paraganglioma, adenoma and adenocarcinoma. Because of its extreme rarity, there is no established standard therapy for tumors in the minor papilla. Endoscopic treatments, including endoscopic mucosal resection, have recently emerged as an alternative to surgery for the limited tumorous condition.
We came across the two cases of submucosal tumor on the minor papilla by performing esophagogastroduodenoscopy for routine check-ups. We performed endoscopic minor papillectomy for the confirmative histologic diagnosis of these submucosal tumors as well as for the treatment, and the ectopic pancreas of the minor papilla was confirmed histologically. We report here on two cases of ectopic pancreas in the minor papilla that were diagnosed and treated by endoscopic minor papillectomy.