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Relationship of low-density lipoprotein particle size to insulin resistance and intima-media thickness in nondiabetic Koreans

Authors
 Jong Suk Park  ;  Jina Park  ;  Chul Sik Kim  ;  Min Ho Cho  ;  Hai Jin Kim  ;  Jeong-Ho Kim  ;  Chul Woo Ahn  ;  Kyung Rae Kim  ;  Bong Soo Cha  ;  Sung Kil Lim  ;  Hyun Chul Lee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.55(12) : 1610-1615, 2006 
Journal Title
 METABOLISM-CLINICAL AND EXPERIMENTAL 
ISSN
 0026-0495 
Issue Date
2006
MeSH
Adult ; Aged ; Atherosclerosis/etiology* ; Carotid Arteries/diagnostic imaging ; Female ; Humans ; Insulin Resistance* ; Lipoproteins, LDL/chemistry* ; Lipoproteins, VLDL/metabolism ; Male ; Middle Aged ; Particle Size ; Regression Analysis ; Tunica Intima/pathology* ; Tunica Media/pathology* ; Ultrasonography
Abstract
The aim of this study was to investigate whether low-density lipoprotein (LDL) particle size is associated with insulin resistance and to explore the association between LDL particle size and preclinical atherosclerosis in nondiabetic Korean population. We measured the carotid intima-media thickness (IMT), LDL particle size, and insulin resistance in 136 nondiabetic subjects. Low-density lipoprotein particle size was significantly correlated with insulin resistance, but the independent risk factors of LDL particle size determined by the multiple regression analysis were age, triglyceride, and high-density lipoprotein cholesterol (HDL-C). Carotid IMT was associated with traditional risk factors of atherosclerosis, which are age, HDL-C, LDL cholesterol, systolic and diastolic blood pressure, but LDL particle size was not correlated with carotid IMT. We conclude that LDL particle size was associated with insulin resistance, but age, triglyceride, and HDL-C contributed independently to the variability in LDL particle size, and LDL particle size was not a predictor of preclinical atherosclerosis in nondiabetic Koreans.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049506002770
DOI
10.1016/j.metabol.2006.07.022
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110422
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