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Generation, culture, and differentiation of human embryonic stem cells for therapeutic applications

Authors
 Shin Yong Moon  ;  Yong Bin Park  ;  Dae-Sung Kim  ;  Sun Kyung Oh  ;  Dong-Wook Kim 
Citation
 MOLECULAR THERAPY, Vol.13(1) : 5-14, 2006 
Journal Title
MOLECULAR THERAPY
ISSN
 1525-0016 
Issue Date
2006
MeSH
Animals ; Blastocyst/cytology* ; Cell Differentiation* ; Cell Lineage ; Cells, Cultured ; Genetic Therapy ; Germ Layers/cytology* ; Humans ; Mice ; Stem Cell Transplantation ; Stem Cells/cytology*
Keywords
embryonic stem cellsgeneration ; culture ; differentiation ; therapeutic application ; manipulation ; therapeutic cloning
Abstract
Embryonic stem (ES) cells, derived from the inner cell mass of the mammalian blastocyst, can continuously proliferate in an undifferentiated state and can also be induced to differentiate into a desired cell lineage. These abilities make ES cells an appealing source for cell replacement therapies, the study of developmental biology, and drug/toxin screening studies. As compared to mouse ES cells, human ES cells have only recently been derived and studied. Although there are many differences in properties between mouse and human ES cells, the study of mouse ES cells has provided important insights into human ES cell research. In this review, we describe the advantages and disadvantages of methods used for human ES cell derivation, the expansion of human ES cells, and the current status of human ES cell differentiation research. In addition, we discuss the endeavor that scientists have undertaken toward the therapeutic application of these cells, which includes therapeutic cloning and the improvement of human ES cell culture conditions.
Full Text
http://www.nature.com/mt/journal/v13/n1/full/mt20064a.html
DOI
10.1016/j.ymthe.2005.09.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0002-5025-1532
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110385
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