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한국형 양극성 장애 약물치료 알고리듬 2006(V):유지치료

Other Titles
 Korean Medication Algorithm for Bipolar Disorder 2006(V):Maintenance Therapy 
 윤보현  ;  박원명  ;  배승오  ;  정상근  ;  김원  ;  신영철  ;  조현상  ;  권준수  ;  서정석  ;  하규섭  ;  민경준  ;  이은  ;  전덕인 
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.17(6) : 528-537, 2006 
Journal Title
Korean Journal of Psychopharmacology(대한정신약물학회지)
Issue Date
Bipolar disorder ; Maintenance ; Pharmacotherapy ; Algorithm.
Objective:Since the previous publication of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) in 2002, there has been a substantial need for the revision of treatment algorithm due to rapid progress in the management for bipolar disorder. We focused on the maintenance treatment of bipolar I and bipolar II disorders of KMAP-BP revised in 2006.
Method:The questionnaire to survey the expert opinion of medication for bipolar disorder was completed by the review committee consisting of 70 experienced psychiatrists. It was composed of 37 questions, and each question includes various sub-items. We classified the expert opinion to 3 categories (the first-line treatment, the second-line, the third-line) by χ² test. A part of this revision regarding maintenance treatment had 6 items;2 on bipolar I and 4 on bipolar II disorder.
Results:There was no ‘treatment of choice’ in maintenance treatment. In case of bipolar I mania without history of depression, mood stabilizer (MS) monotherapy was 1st-line treatment. In maintenance management for bipolar II disorder, two treatment options were recommended. Treatment with MS alone or combinations of MS and atypical antipsychotics were preferred in recently recovered patients from hypomania. Atypical antipsychotics were more favored in the maintenance treatment for bipolar I and II disorders than previous KMAP-BP.
Conclusions:There is no ‘treatment of choice’ in maintenance strategies for bipolar disorder. Atypical antipsychotics are more preferred than the previous KMAP-BP. Also there is an increasing interest on the maintenance use of lamotrigine in bipolar depression.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Hyun Sang(조현상) ORCID logo https://orcid.org/0000-0003-1019-9941
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