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경도인지장애에서 뇌자기공명영상검사상 백질병소에 관한 연구

Other Titles
 White Matter Lesions on Magnetic Resonance Imaging Mild Cognitive Impairment 
 전진숙  ;  전갑수  ;  조원용  ;  송혜란  ;  오병훈 
 Journal of the Korean Society of Biological Therapies in Psychiatry (생물치료정신의학), Vol.12(1) : 93-103, 2006 
Journal Title
 Journal of the Korean Society of Biological Therapies in Psychiatry (생물치료정신의학) 
Issue Date
Mild cognitive impairment ; White matter lesions ; Deep white matter hyperintensities ; Periventricular hyperintensities ; Hypertension
Objectives : The aims of this study were to know the frequency of white matter lesions(WMLs) on brain magnetic resonance imaging(MRI) in patients with mild cognitive impairment(MCI), and to identify related factors. Methods : Among WMLs, periventricular hyperintensities(PVHs) and deep white matter hyperintensities(DWMHs) on brain MRI in patients with MCI(N=30), patients with dementia of the Alzheimer's type (DAT)(N=34) and normal aged controls(N=20) were analyzed. Furthermore, related variables including cardiovascular risk factors were discussed. Results : 1) The frequencies of the third degree PVHs in patients with MCI(16.6%) were significantly different from those of normal aged controls(5.0%), and from those of patients with DAT(38.2%)(p<0.05). However, frequencies of the third degree DWMHs in patients with MCI(23.3%) were not different from those of normal aged controls(10.0%), and from those of patients with DAT(35.3%). 2) The frequencies of various cardiovascular risk factors in patients with MCI, patients with DAT and normal aged controls were not significantly different. 3) The severity of PVLs seemed to be related to age(p<0.05), systolic blood pressure(p<0.05) and diastolic blood pressure(p<0.005). The severity of DWMHs were seemed to be related to sex(p<0.05), education(p<0.05), Global Deterioration Scale(p<0.05), systolic blood pressure(p<0.01) and diastolic blood pressure(p<0.05). Conclusion : The PVHs might be useful to discriminate patients with MCI from normal aged person. Active management of hypertension seemed to be crucial to prevent from development of WMLs.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Byong Hoon(오병훈)
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