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Increasing trend in the prevalence of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae lacking chromosomal ampC gene at a Korean university hospital from 2002 to 2004

Authors
 Wonkeun Song  ;  Jae-Seok Kim  ;  Han-Sung Kim  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Min-Jeong Park  ;  Kyu Man Lee 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.55(3) : 219-224, 2006 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2006
MeSH
Bacterial Proteins/genetics* ; Chi-Square Distribution ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/enzymology* ; Enterobacteriaceae/genetics ; Humans ; Korea ; Microbial Sensitivity Tests/methods ; Plasmids/drug effects ; Plasmids/genetics* ; beta-Lactamases/genetics*
Keywords
Klebsiella spp. ; Salmonella spp. ; Plasmid-mediated AmpC β-lactamases ; Korea
Abstract
The aim of the study is to investigate the prevalence of plasmid-mediated AmpC β-lactamases in Enterobacteriaceae naturally lacking chromosomal AmpC β-lactamases. A total of 1860 clinical isolates of Klebsiella spp., Salmonella spp., and Proteus mirabilis were collected from a Korean hospital between January 2002 and December 2004. For the isolates that are nonsusceptible to cefoxitin, polymerase chain reaction amplification of the blaSHV, blaTEM, and blaAmpC genes and sequencing were performed. Plasmid-mediated AmpC β-lactamases were found in 2.9% (37 isolates of DHA-1, 1 isolate of CMY-1, 1 isolate of CMY-2, and 1 isolate of ACT-1) of Klebsiella pneumoniae, 2.5% (5 isolates of DHA-1) of Klebsiella oxytoca, 0.8% (1 isolate of DHA-1) of Salmonella spp., and none of P. mirabilis isolates. The DHA-1–producing K. pneumoniae was only 2 isolates (0.6%) in 2002, but the rate and the number significantly increased to 2.4% (13 of 538 isolates) in 2003 and to 4.3% (22 of 512) in 2004. In conclusion, DHA-1 is the most prevalent plasmid-mediated AmpC β-lactamase in Enterobacteriaceae lacking chromosomal ampC gene, and the DHA-1–producing K. pneumoniae isolates have rapidly increased since 2003 in a Korean hospital. In addition, this is the first report of the appearance of a K. pneumoniae isolate producing ACT-1 β-lactamase in Korea.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889306000149
DOI
10.1016/j.diagmicrobio.2006.01.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110318
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