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Estrogen receptor gene polymorphism and craniofacial morphology in female TMJ osteoarthritis patients

Authors
 D.-G. Lee  ;  T.-W. Kim  ;  S.-C. Kang  ;  S.T. Kim 
Citation
 INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, Vol.35(2) : 165-169, 2006 
Journal Title
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
ISSN
 0901-5027 
Issue Date
2006
MeSH
Adolescent ; Adult ; Cephalometry ; Chi-Square Distribution ; Estrogen Receptor alpha/genetics* ; Female ; Humans ; Mandible/anatomy & histology ; Mandible/diagnostic imaging ; Middle Aged ; Osteoarthritis/genetics* ; Polymorphism, Genetic* ; Radiography ; Skull/anatomy & histology* ; Skull/diagnostic imaging ; Statistics, Nonparametric ; Temporomandibular Joint Disorders/genetics*
Abstract
The aim of this study was to investigate the possible influence of estrogen receptor alpha (ERalpha) polymorphism on the craniofacial skeleton in female patients suffering from symptomatic osteoarthritis (OA) of the temporomandibular joint (TMJ). The sample comprised 76 genetically unrelated Korean women diagnosed with OA by research diagnostic criteria for temporomandibular disorders (RDC-TMD). Direct haplotyping procedure was used to analyze the PvuII and XbaI RFLPs. Twelve cephalometric measurements were taken to evaluate the spatial position and dimensions of the mandible. Mann-Whitney's U-test was used to identify the potential differences in the cephalometric measurements between the subjects grouped according to their carrier status for Px haplotype. In addition, an association study was carried out using chi(2)-test to further examine the relationship between Px haplotype and the craniofacial morphology of the symptomatic OA patients. Female symptomatic TMJ OA patients carrying Px haplotype showed significantly smaller facial axis angle (P<0.05) and mandibular body length (P<0.05) than the non-carriers. The association between the presence of Px haplotype and short mandibular body length was also ascertained. This study suggests that ERa polymorphism contributes to the altered mandibular dimensions in female symptomatic TMJ OA patients. Further studies on the role of the genetic markers relevant to the craniofacial growth and adaptation are expected to broaden our understanding of determinants of the craniofacial morphology.
Full Text
http://www.sciencedirect.com/science/article/pii/S0901502705002171
DOI
10.1016/j.ijom.2005.06.009
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Taek(김성택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110290
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