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Bile acid analysis in biliary tract cancer

 Jeong Youp Park  ;  Byung Kyu Park  ;  Jun Sang Ko  ;  Seungmin Bang  ;  Si Young Song  ;  Jae Bock Chung 
 YONSEI MEDICAL JOURNAL, Vol.47(6) : 817-825, 2006 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biliary Tract Neoplasms/chemistry* ; Biliary Tract Neoplasms/metabolism ; Biomarkers, Tumor/analysis ; Cholelithiasis/metabolism ; Cholic Acids/analysis* ; Cholic Acids/metabolism ; Female ; Gallbladder Neoplasms/metabolism ; Humans ; Male ; Middle Aged
Bile ; bile acid ; biliary tract cancer
The etiology of biliary tract cancer is obscure, but there are evidences that bile acid plays a role in carcinogenesis. To find the association between biliary tract cancer and bile acid, this study compared the bile acid concentration and composition among patients with biliary cancer, biliary tract stones, and no biliary disease. Bile was compared among patients with biliary tract cancer (n = 26), biliary tract stones (n = 29), and disease free controls (n = 9). Samples were obtained by percutaneous transhepatic biliary drainage, endoscopic nasobiliary drainage, or gallbladder puncture, and analyzed for cholic, deoxycholic, chenodeoxycholic, lithocholic, and ursodeoxycholic acid composition. Total bile acid concentration was lower in the cancer group than the biliary stone and control groups; the proportions of deoxycholic (2.2% vs. 10.2% and 23.6%, p <0.001 and p <0.001, respectively) and lithocholic acid (0.3% vs. 0.6% and 1.0%, p = 0.065 and p <0.001, respectively) were also lower. This result was similar when disease site was limited to bile duct or gallbladder. Analysis of cases with bilirubin ≤ 2.0 mg/dL also showed lower total bile acid concentration and deoxycholic acid composition in the cancer group compared to controls (5.7% vs. 23.6%, p = 0.003). Although the presence of bile duct obstruction explains some of the difference in total concentration and composition of bile acid, there are other contributing mechanisms. We suspect the alteration of bile acid transport might decrease bile acid excretion and cause the accumulation of carcinogenic bile acid in bile duct epithelium.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Jun Sang(고준상)
Park, Byung Kyu(박병규)
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
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