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과민성 장증후군 환자에서 생균제의 효과

Other Titles
 The Effects of Probiotics on Symptoms of Irritable Bowel Syndrome 
 김영균  ;  문종태  ;  이근만  ;  전누리  ;  박효진 
 Korean Journal of Gastroenterology, Vol.47(6) : 413-419, 2006 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Irritable bowel syndrome ; Inflammation ; Abnormal intestinal motility
Background/Aims: Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) tract disorder that has heterogeneous clinical presentations such as abdominal pain, diarrhea, constipation, and abdominal distension. It is known that several mechanisms are involved in the pathogenesis of IBS. Probiotics may target one or more pathophysiologic pathways in IBS and may improve the symptoms of IBS. However, the results of studies about probiotics on IBS are controversial. Therefore, the aim of this study was to evaluate the effect of probiotics on GI symptoms and intestinal gas volume changes in patients with IBS. Methods: Forty patients were randomly allocated to be treated with medilac DS® (Bacillus subtilis, Streptococcus faecium) (n=20) or placebo (n=20) in a double-blind, prospective manner. The change in intestinal gas volume and symptom scores after 4-week treatment were evaluated for the efficacy. Results: There was no significant difference in bloating, frequency of gas expulsion, frequency of defecation, and hardness of stool before and after the treatment. However, the severity of abdominal pain and the frequency of abdominal pain decreased significantly in medilac DS® group (2.4±1.3 cm/ day→1.6±1.6 cm/day, 1.7±1.3/day→1.0±1.0/day) (p=0.044, p=0.038), but not in placebo group (2.1±2.0 cm/day →1.8±2.1 cm/day, 1.3±1.2/day→1.4±1.9/day). In both groups, intestinal gas volume at baseline, after 2-week treatment, and after 4-week treatment did not show significant change. Medilac DS® was well tolerated without adverse events. Conclusions: Medilac DS® is a safe and useful probiotic agent for the treatment of abdominal pain in patients with IBS
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
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