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High prevalence of ceftazidime-resistant Klebsiella pneumoniae and increase of imipenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. in Korea: A KONSAR Program in 2004

 Kyungwon Lee  ;  Chang Hyun Lim  ;  Ji Hyun Cho  ;  Wee Gyo Lee  ;  Young Uh  ;  Hwi Jun Kim  ;  Dongeun Yong  ;  Yunsop Chong 
 YONSEI MEDICAL JOURNAL, Vol.47(5) : 634-645, 2006 
Journal Title
Issue Date
Acinetobacter/drug effects ; Acinetobacter/isolation & purification ; Anti-Bacterial Agents/pharmacology* ; Ceftazidime/pharmacology* ; Drug Resistance, Multiple, Bacterial ; Gammaproteobacteria/drug effects* ; Gammaproteobacteria/isolation & purification ; Hospitals ; Imipenem/pharmacology* ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Korea ; Laboratories ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/isolation & purification
Antimicrobial resistance surveillance ; Korea ; ceftazidime resistance ; imipenem resistance
A nationwide antimicrobial resistance surveillance has been conducted since 1997 in Korea. In this study, susceptibility test data generated in 2004 by KONSAR group hospitals were analyzed and compared to those at a commercial laboratory. In hospitals, the rank orders of organisms in 2004 were identical to those in 2003. The most prevalent species was Staphylococcus aureus (20.2%) in hospitals, but Escherichia coli (29.7%) in the commercial laboratory. The proportions of Enterococcus faecium to all isolates of Enterococcus faecalis plus E. faecium were 47.2% in hospitals and 24.9% in the commercial laboratory. The mean resistance rates of significant antimicrobial-organism combinations in hospitals were: oxacillin-resistant S. aureus (68%), oxacillin-resistant (penicillin-nonsusceptible) Streptococcus pneumoniae (68%), vancomycin-resistant E. faecium (25%), cefotaxime-resistant E. coli (14%), ceftazidime- and cefoxitin-resistant Klebsiella pneumoniae (34% and 32%, respectively), and imipenem-resistant Acinetobacter spp. and Pseudomonas aeruginosa (17% and 24%, respectively). In conclusion, oxacillin-resistant staphylococci, expanded-spectrum cephalosporin-resistant K. pneumoniae, and imipenem-resistant Acinetobacter spp. and P. aeruginosa were prevalent in 2004. Increasing trends were observed for vancomycin-resistant E. faecium, cefoxitin-resistant E. coli and K. pneumoniae, and imipenem-resistant Acinetobacter spp. and P. aeruginosa. Certain antimicrobial-organism combinations were also prevalent among the commercial laboratory-tested strains.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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