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Cigarette smoking, elevated fasting serum glucose, and risk of pancreatic cancer in Korean men

Authors
 Ji Eun Yun  ;  Inho Jo  ;  Jungyong Park  ;  Miyong T. Kim  ;  Hwang Gun Ryu  ;  Nemekhee Odongua  ;  Eunkyung Kim  ;  Sun Ha Jee 
Citation
 INTERNATIONAL JOURNAL OF CANCER, Vol.119(1) : 208-212, 2006 
Journal Title
INTERNATIONAL JOURNAL OF CANCER
ISSN
 0020-7136 
Issue Date
2006
MeSH
Adult ; Aged ; Blood Glucose/metabolism* ; Fasting ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Odds Ratio ; Pancreatic Neoplasms/epidemiology* ; Pancreatic Neoplasms/etiology* ; Proportional Hazards Models ; Risk Assessment ; Risk Factors ; Smoking/adverse effects* ; Smoking/epidemiology ; Surveys and Questionnaires
Keywords
pancreatic cancer ; smoking ; fasting serum glucose ; diabetes ; cohort study
Abstract
Pancreatic cancer is one of the most fatal human cancers and continues to be a major unsolved health problem. The goal of this study was to estimate the independent effects and interactions between cigarette smoking and diabetes on the risk of pancreatic cancer in Korean male population. Cigarette smoking and the risk of incidence and death from pancreatic cancer were examined in a 10-year prospective cohort study of 446,407 Korean men aged 40 to 65 years who received health insurance from the National Health Insurance Corporation and who had a medical evaluation in 1992. Relative risks (RR) and 95% confidence intervals (CI) were calculated using a Cox proportional hazards model after adjusting for age, body mass index, exercise and alcohol use. Current smoking was associated with an increased risk of incidence (RR = 1.7, 95% CI = 1.6–1.9) and mortality (RR = 1.6, 95% CI = 1.4–1.7) from pancreatic cancer. The RR for pancreatic cancer increased with both duration and amount of smoking. Diabetes was also associated with an increased risk of both incidence (RR = 1.8, 95% CI = 1.5–2.2) and mortality (RR = 1.7, 95% CI = 1.4–2.1) from pancreatic cancer. There was no interaction between smoking and fasting serum glucose in terms of pancreatic cancer risk. Thus, our prospective study has demonstrated that cigarette smoking and elevated fasting serum glucose are independently associated with an increased risk of pancreatic cancer in a large cohort of Korean males.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ijc.21816/abstract
DOI
10.1002/ijc.21816
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110038
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