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Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma

Authors
 Chul-Ho Kim  ;  Sung-Kyun Moon  ;  Joon-Ho Bae  ;  Jae Ho Lee  ;  Jae Ho Han  ;  Kyubo Kim  ;  Eun Chang Choi 
Citation
 ACTA OTO-LARYNGOLOGICA, Vol.126(1) : 88-94, 2006 
Journal Title
ACTA OTO-LARYNGOLOGICA
ISSN
 0001-6489 
Issue Date
2006
MeSH
Adult ; Aged ; Blotting, Western ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology* ; Gene Expression Regulation, Neoplastic ; Hepatocyte Growth Factor/genetics ; Hepatocyte Growth Factor/metabolism* ; Humans ; Hypopharyngeal Neoplasms/metabolism ; Hypopharyngeal Neoplasms/pathology* ; Immunohistochemistry ; Middle Aged ; Neoplasm Staging ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism* ; RNA/analysis ; Reverse Transcriptase Polymerase Chain Reaction
Keywords
c-Met ; hepatocyte growth factor ; hypopharyngeal cancer
Abstract
Conclusion. Our results suggest that hepatocyte growth factor (HGF) may play an important role in the progression of hypopharyngeal cancer. Objective. HGF, a potent stimulator of hepatocyte growth, stimulates the motility, invasiveness, proliferation and morphogenesis of epithelium and may be involved in physiologic and pathologic processes such as embryogenesis, wound healing, organ regeneration, inflammation and tumor invasion. We therefore examined the role of HGF and c-Met in the invasion and metastasis of hypopharyngeal squamous cell carcinoma (SCC). Material and methods. We performed immunohistochemical staining of 40 specimens each of normal mucosa and SCC of the hypopharynx with HGF and c-Met antibodies. For reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting, fresh normal and cancer tissue from the hypopharynx obtained from five patients were used. Results. Positive rates of HGF and c-Met expression in hypopharyngeal SCC were 77.5% and 70%, respectively. HGF staining was significantly correlated with lymph node metastasis and pathologic stage (p < 0.05). c-Met staining was only significantly correlated with lymph node metastasis (p < 0.05). Increased expression of c-Met mRNA (RT-PCR) and protein (Western blotting) was detected in hypopharyngeal cancer tissue.
Full Text
http://informahealthcare.com/doi/abs/10.1080/00016480510037014
DOI
10.1080/00016480510037014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/110011
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