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Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanisms

 Z. H. Cho  ;  S. C. Hwang  ;  E. K. Wong  ;  Y. D. Son1  ;  C. K. Kang  ;  T. S. Park  ;  S. J. Bai  ;  Y. B. Kim  ;  Y. B. Lee  ;  K. K. Sung  ;  B. H. Lee  ;  L. A. Shepp  ;  K. T. Min 
 ACTA NEUROCHIRURGICA, Vol.113(6) : 370-377, 2006 
Journal Title
Issue Date
Acupuncture Therapy* ; Animals ; Central Nervous System/anatomy & histology ; Central Nervous System/physiology* ; Humans ; Hypothalamo-Hypophyseal System/anatomy & histology ; Hypothalamo-Hypophyseal System/physiology* ; Inflammation/immunology ; Inflammation/physiopathology ; Models, Neurological ; Neuroimmunomodulation/physiology* ; Neurosecretory Systems/physiology* ; Pituitary-Adrenal System/anatomy & histology ; Pituitary-Adrenal System/physiology* ; Stress, Physiological/immunology ; Stress, Physiological/physiopathology
acupuncture ; acupuncture mechanism ; stress‐induced hypothalamus–pituitary–adrenal axis ; broad‐sense hypothalamus–pituitary–adrenal axis ; neuroimmunology ; functional brain imaging
OBJECTIVES: Although acupuncture therapy has demonstrated itself to be effective in several clinical areas, the underlying mechanisms of acupuncture in general and the analgesic effect in particular are, however, still not clearly delineated. We, therefore, have studied acupuncture analgesic effect through fMRI and proposed a hypothesis, based on the obtained result, which will enlighten the central role of the brain in acupuncture therapy. METHODS: The proposed model, termed as a broad sense hypothalamus-pituitary-adrenal (BS-HPA) axis, was based on our observed neuroimaging results. The model incorporates the stress-induced HPA axis model together with neuro-immune interaction including the cholinergic anti-inflammatory model. RESULTS: The obtained results coupled with accumulating evidence suggest that the central nervous system is essential for the processing of these effects via its modulation of the autonomic nervous system, neuroimmune system and hormonal regulation. CONCLUSIONS: Based on our fMRI study, it appears that understanding the effects of acupuncture within a neuroscience-based framework is vital. Further, we have proposed the broad sense-HPA axis hypothesis which incorporates the experimental results.
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1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
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