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A phase II trial of fractionated irinotecan plus carboplatin for previously untreated extensive-disease small cell lung cancer

Authors
 Joo Hyuk Sohn  ;  Hye Jin Choi  ;  Joon Chang  ;  Se Kyu Kim  ;  Chang Geal Lee  ;  Kyung Young Chung  ;  Dae Joon Kim  ;  Byoung Chul Cho  ;  Sang Joon Shin  ;  Yong Wha Moon  ;  Joo-Hang Kim 
Citation
 Lung Cancer, Vol.54(3) : 365-370, 2006 
Journal Title
 Lung Cancer 
ISSN
 0169-5002 
Issue Date
2006
Abstract
PURPOSE: Irinotecan plus cisplatin has been previously documented to be effective in the treatment of extensive-disease small cell lung cancer (ED-SCLC). This study was undertaken to investigate the efficacy and feasibility of combination chemotherapy of irinotecan and carboplatin in previously untreated ED-SCLC. PATIENTS AND METHODS: From December 2002 to October 2005, 39 patients with previously untreated ED-SCLC were enrolled. Patients were treated with irinotecan (50mg/m(2) IV on days 1, 8, and 15) and carboplatin (target AUC=5 IV on day 1) every 4 weeks for up to six cycles. RESULTS: Thirty-four patients (87.2%) were male and the median age was 65 years. ECOG performance status was 0-1 in 20 (51.3%) patients and 2 in 19 (48.7%) patients. The median number of chemotherapy cycles was six (range: 1-6 cycles). Thirty-five patients were assessable for response evaluation. The overall response rate was 69.2% (1 CR, 26 PR) under the intent-to-treat analysis. After a median follow-up of 22.7 months, the median time to progression was 6.4 months (95% confidence interval [CI]: 5.7-7.1 months) and median overall survival was 11.0 months (95% CI: 9.9-12.0 months). The estimated 1-year survival rate was 42.5%. In terms of toxicities, Grade 3/4 neutropenia and thrombocytopenia occurred in eight (25.6%) and five (15.4%) patients, respectively. Grade 3/4 non-hematologic toxicities included diarrhea (10.3%), anorexia (7.7%), infection (10.3%), and neutropenic fever (12.8%). There was one treatment-related death due to superimposed infection on the broncho-pleural fistula. CONCLUSION: The combination chemotherapy of irinotecan and carboplatin was effective and tolerable in previously untreated ED-SCLC patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0169500206004582
DOI
10.1016/j.lungcan.2006.08.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김대준(Kim, Dae Joon)
김세규(Kim, Se Kyu)
김주항(Kim, Joo Hang)
손주혁(Sohn, Joo Hyuk) ORCID logo https://orcid.org/0000-0002-2303-2764
이창걸(Lee, Chang Geol) ORCID logo https://orcid.org/0000-0002-8702-881X
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정경영(Chung, Kyung Young)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109959
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