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Further increase of vancomycin-resistant Enterococcus faecium, amikacin- and fluoroquinolone-resistant Klebsiella pneumoniae, and imipenem-resistant Acinetobacter spp. in Korea: 2003 KONSAR surveillance

 Kyungwon Lee  ;  Ki Hyung Park  ;  Seok Hoon Jeong  ;  Hwan Sub Lim  ;  Jong Hee Shin  ;  Dongeun Yong  ;  Gyoung-yim Ha  ;  Yunsop Chong 
 Yonsei Medical Journal, Vol.47(1) : 43-54, 2006 
Journal Title
 Yonsei Medical Journal 
Issue Date
Acinetobacter/drug effects ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology Amikacin/pharmacology ; Anti-Bacterial Agents/pharmacology* ; Drug Resistance, Bacterial* ; Enterococcus faecium/drug effects* ; Enterococcus faecium/isolation & purification ; Fluoroquinolones/pharmacology ; Gammaproteobacteria/drug effects* ; Gammaproteobacteria/isolation & purification ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/epidemiology ; Gram-Negative Bacterial Infections/microbiology* ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology* ; Humans ; Imipenem/pharmacology ; Klebsiella Infections/drug therapy ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/isolation & purification ; Korea/epidemiology ; Microbial Sensitivity Tests ; Population Surveillance ; Vancomycin/pharmacology ; Vancomycin Resistance
Antimicrobial resistance surveillance ; Korea ; vancomycin resistance ; fluoroquinolone resistance ; imipenem resistance
Monitoring temporal trends of antimicrobial resistance can provide useful information for the empirical selection of antimicrobial agents to treat infected patients and for the control of nosocomial infections. In this study, we analyzed antimicrobial resistance of clinically relevant bacteria in 2003 at Korean hospitals and at a commercial laboratory. The following organism-antimicrobial agent resistance combinations were very prevalent: oxacillin-resistant Staphylococcus aureus (68%), expanded-spectrum cephalosporin-resistant Klebsiella pneumoniae (25%), and fluoroquinolone-resistant Escherichia coli (33%), Acinetobacter spp. (58%), and Pseudomonas aeruginosa (40%). Moreover, gradual increases in vancomycin-resistant Enterococcus faecium (20%), cefoxitin-resistant E. coli (10%) and K. pneumoniae (23%), and imipenem-resistant P. aeruginosa (20%) and Acinetobacter spp. (13%) were also observed. The resistance rates of Acinetobacter spp. to most antimicrobial agents at hospitals and at the commercial laboratory were similar. Among the Acinetobacter spp. isolated at a tertiary-care hospital, 46.2% were multidrug-resistant to 9-12 of 13 antimicrobial agents, and 18.3% were panresistant. The exclusion of duplicate isolates at a tertiary-care hospital significantly lowered the proportion of oxacillin-resistant S. aureus, vancomycin-resistant E. faecium, and fluoroquinolone-resistant E. coli.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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