Cited 19 times in
The expression of RAGE and EN-RAGE in leprosy
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-06-10T12:28:26Z | - |
dc.date.available | 2015-06-10T12:28:26Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0007-0963 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109866 | - |
dc.description.abstract | BACKGROUND: Extracellular newly identified RAGE-binding protein (EN-RAGE) is a ligand of the receptor for advanced glycation endproducts (RAGE) and has been termed S100A12. The ligation of EN-RAGE with RAGE on the endothelium, mononuclear phagocytes and lymphocytes triggers cellular activation with the generation of the key proinflammatory mediators interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha. OBJECTIVES: The aim of this study was to investigate the presence of RAGE and EN-RAGE, their spatial localization and their coexpression in leprosy lesions. METHODS: Immunohistochemistry and confocal laser scanning microscopy were used to evaluate the expression of RAGE and EN-RAGE in leprosy. By enzyme-linked immunosorbent assay, RAGE and EN-RAGE were detected in the serum. RESULTS: (1) In the multibacillary (MB) and paucibacillary (PB) groups, the level of RAGE production was significantly higher than in patients with atypical mycobacterial infection or sarcoidosis (P < 0.01). In the MB group, the production of RAGE was higher than in the PB group (P < 0.01), and it was higher in patients without the lepra reaction than in patients with the lepra reaction (P < 0.05). (2) In MB, PB and atypical mycobacterial infection, the level of EN-RAGE production was significantly higher than in sarcoidosis (P < 0.01). (3) In the confocal laser scanning microscopic examination, the RAGE and EN-RAGE proteins were detected in lepromatous leprosy. These proteins are spatially colocalized along the cell surface, which is in agreement with their receptor-ligand interaction. (4) A comparable amount of EN-RAGE was detected in the serum of the MB and PB groups. Patients with the reaction showed a higher level of EN-RAGE than patients without the reaction in leprosy. CONCLUSIONS: Our data suggest that in leprosy, RAGE and EN-RAGE may be involved in the proinflammatory process rather than the antimycobacterial activity, especially during the lepra reaction. The blockade of the interaction of RAGE and EN-RAGE at the early stage of the inflammatory process may minimize the inflammatory response and consequent tissue damage or the sequelae of leprosy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 594~601 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay/methods | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Leprosy/metabolism* | - |
dc.subject.MESH | Microscopy, Confocal | - |
dc.subject.MESH | Mycobacterium Infections, Nontuberculous/metabolism | - |
dc.subject.MESH | Receptor for Advanced Glycation End Products | - |
dc.subject.MESH | Receptors, Immunologic/biosynthesis | - |
dc.subject.MESH | Receptors, Immunologic/metabolism* | - |
dc.subject.MESH | S100 Proteins/biosynthesis | - |
dc.subject.MESH | S100 Proteins/metabolism* | - |
dc.subject.MESH | S100A12 Protein | - |
dc.subject.MESH | Sarcoidosis/metabolism | - |
dc.subject.MESH | Skin/metabolism | - |
dc.title | The expression of RAGE and EN-RAGE in leprosy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | M-H. Kim | - |
dc.contributor.googleauthor | Y.W. Choi | - |
dc.contributor.googleauthor | H.Y. Choi | - |
dc.contributor.googleauthor | K.B. Myung | - |
dc.contributor.googleauthor | S.N. Cho | - |
dc.identifier.doi | 10.1111/j.1365-2133.2005.07112.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J00408 | - |
dc.identifier.eissn | 1365-2133 | - |
dc.identifier.pmid | 16536799 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2005.07112.x/abstract | - |
dc.subject.keyword | atypical mycobacterial infection | - |
dc.subject.keyword | EN‐RAGE | - |
dc.subject.keyword | leprosy | - |
dc.subject.keyword | RAGE | - |
dc.subject.keyword | S100A12 | - |
dc.subject.keyword | sarcoidosis | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 154 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 594 | - |
dc.citation.endPage | 601 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF DERMATOLOGY, Vol.154(4) : 594-601, 2006 | - |
dc.identifier.rimsid | 50648 | - |
dc.type.rims | ART | - |
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