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The Role of Gamma Knife Radiosurgery for Diffuse Astrocytomas

 Kyung Hyun Kim  ;  Yong Sook Park  ;  Jong Hee Chang  ;  Jin Woo Chang  ;  Yong Gou Park 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.39(2) : 102-108, 2006 
Journal Title
Journal of Korean Neurosurgical Society(대한신경외과학회지)
Issue Date
Diffuse astrocytoma ; Gamma Knife radiosurgery ; Radiologic response
Objective:The management of diffuse astrocytomas is one of the most controversial areas in clinical neurooncology. There are numerous reviews and editorials outlining the difficulties in the management of these lesions. In this study, we assess the role of Gamma Knife radiosurgery(GKS) for diffuse astrocytomas.

Methods : Twenty-three patients with a diffuse astrocytoma were treated with GKS as a primary or adjuvant method from February 1995 to October 2003. The mean marginal dose was 13.6 (8.5~17.5)Gy and the mean maximal dose was 27.3 (17.0~ 35.0)Gy. Local control and the pattern of radiologic response were evaluated. The probable factors affecting local control, such as tumor volume, margin dose, previous history of craniotomy or stereotactic biopsy, and the presence or absence of previous radiotherapy were statistically analyzed. The average duration of follow-up was 39.7 (11.3~101.5) months after GKS.

Results : Of the 23 lesions treated, 16 lesions (69.6%) were controlled during the follow-up period. The mean progression-free interval was 57.4 months and the 5-year progression-free rate was 68%. Only tumor volume was found to be a statistically significant factor for local control. Smaller tumors were better controlled by GKS; it was significantly effective in tumors with less than a 10cm3 volume.

Conclusion : GKS could be a valuable therapeutic modality both as a primary treatment and as a postoperative adjuvant therapy in some selected cases.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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