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Plasma factor XIII activity in patients with disseminated intravascular coagulation

 Jae Woo Song  ;  Jong Rak Choi  ;  Kyung Soon Song  ;  Ji-Hyuk Rhee 
 Yonsei Medical Journal, Vol.47(2) : 196-200, 2006 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Aged ; Blood Coagulation Tests ; Cross-Linking Reagents/pharmacology ; Cross-Linking Reagents/therapeutic use ; Disseminated Intravascular Coagulation/blood* ; Disseminated Intravascular Coagulation/diagnosis* ; Factor XIII/biosynthesis* ; Female ; Fibrin Fibrinogen Degradation Products/biosynthesis ; Hemostasis ; Humans ; Inflammation ; Kidney/pathology ; Kidney Diseases/pathology ; Liver/pathology ; Liver Diseases/pathology ; Male ; Middle Aged ; Partial Thromboplastin Time ; Platelet Count ; Prothrombin Time
Disseminated intravascular coagulation ; factor XIII ; hemostasis
The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis. Citrated plasma from eighty patients with potential DIC was analyzed for FXIII activity. The primary patient conditions (48 male and 32 female, mean age, 51 years) were malignancy (n = 29), infection (n = 25), inflammation (n = 6), heart disease (n = 3), thrombosis (n = 2), injury (n = 2), and other miscellaneous conditions (n = 13). FXIII testing was performed using the CoaLinkTM FXIII Incorporation Assay Kit (PeopleBio Inc.). Among 80 patients who were suspected to have DIC based on clinical analysis, 46 (57.5%) fulfilled the overt DIC criteria (DIC score >= 5) according to the International Society of Thrombosis and Haemostasis. FXIII levels in the plasma were significantly decreased in overt DIC compared to non-overt DIC patients (mean 75.1% and 199.7% respectively, p <0.0001). Interestingly, we found a significant inverse correlation between DIC scores and FXIII activity. In addition, FXIII activity significantly correlated with other hemostatic markers that included platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, and D-dimer. FXIII levels were significantly lower in patients with liver or renal dysfunction. In conclusion, FXIII cross-linking activity measurements may have differential diagnostic value as well as predictive value in patients who are suspected to have DIC.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Kyung Soon(송경순)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
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