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알파비-크리스탈린 단백질 전달에 의한 심근세포 보호

Other Titles
 Cardiac Cell Protection by Intracellular Delivery of Crystallin-αB using a Protein Transduction Domain 
Authors
 정지형  ;  황기철  ;  장양수 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.3(3) : 268-272, 2006 
Journal Title
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE 
ISSN
 1738-2696 
Issue Date
2006
Keywords
Cell death ; crystalline-αB ; apoptosis
Abstract
The overexpression of crystallin-αB confers protection against ischemia/reperfusion, hypoxia/reoxygenation, hypertonic stress and reactive oxygen stresses. Some evidences have suggested that increasing the expression of crystallin-αB represents a potential therapeutic strategy for the cardiac injury. In this study, we studied the potential cytoprotective effect of HSP27 as a therapeutic protein using protein transduction domain system in cardiac cells. Crystallin-αB gene was fused with a gene fragment encoding TAT protein transduction domain in a bacterial expression vector. TAT-crystallin-αB protein was rapidly transduced into cardiac cells. Its transduction showed cytoprotective effect against the hypoxic stress, which was accompanied by reduced caspase-3 activity. These results suggest that delivered TAT-crystallin might protect cell death from hypoxic stress by modulating caspase activation pathway in vitro and this may be of potential therapeutic benefit in ischemic diseases
Full Text
http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=3118775
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hwang, Ki Chul(황기철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109817
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