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Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo: Berberine improves neointima formation in a rat model

Authors
 Seahyoung Lee  ;  Hyun-Joung Lim  ;  Hyun-Young Park  ;  Kuy-Sook Lee  ;  Jin-Hee Park  ;  Yangsoo Jang 
Citation
 ATHEROSCLEROSIS, Vol.186(1) : 29-37, 2006 
Journal Title
ATHEROSCLEROSIS
ISSN
 0021-9150 
Issue Date
2006
MeSH
Angioplasty, Balloon/adverse effects ; Angiotensin II/antagonists & inhibitors ; Angiotensin II/metabolism ; Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/injuries ; Aorta, Thoracic/pathology ; Berberine/pharmacology* ; Blotting, Western ; Carotid Artery Injuries/pathology ; Carotid Artery Injuries/prevention & control ; Carotid Artery, Common/drug effects ; Carotid Artery, Common/metabolism ; Carotid Artery, Common/pathology ; Cell Movement/drug effects* ; Cell Proliferation/drug effects* ; Cells, Cultured ; Disease Models, Animal ; Epidermal Growth Factor/antagonists & inhibitors ; Epidermal Growth Factor/metabolism ; Heparin-binding EGF-like Growth Factor ; In Vitro Techniques ; Intercellular Signaling Peptides and Proteins ; Male ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology* ; Rats ; Rats, Sprague-Dawley ; Tunica Intima/drug effects ; Tunica Intima/injuries ; Tunica Intima/pathology*
Keywords
Berberine ; Neointima ; Vascular smooth muscle cell (VSMC)
Abstract
Berberine, an alkaloid isolated from Chinese medicinal herbs, long been known for its anti-microbial activity and used to treat various infectious disorders in traditional Chinese medicine. In the present study, we have tested the hypothesis that berberine could inhibit vascular smooth muscle cell (VSMC) proliferation as it did in endothelial cells or cancer cells. Our results show that berberine significantly inhibits growth factor, mainly angiotensin II (AngII) and heparin binding epidermal growth factor (HB-EGF), induced VSMC proliferation and migration in vitro, and this effect is achieved by delaying or partially suppressing activation of Akt pathway rather than ERK pathway. Furthermore, we have examined its effect in vivo using a rat carotid artery injury model. A 28 days of chronic berberine treatment using an osmotic pump (100 μg kg−1 d−1, 2 weeks before and 2 weeks after the injury) improved neointima formation. The Neointima/Media ratio for control group and berberine treated group were 1.14 ± 0.11 and 0.85 ± 0.06 (p < 0.05), respectively, and the reduction was approximately 25%. The result of the present study suggests a possibility of berberine being a potent agent to control restenosis after balloon angioplasty and warrants further study to gain a more complete understanding of its underlying mechanisms at a cellular level.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915005004508
DOI
10.1016/j.atherosclerosis.2005.06.048
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109812
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