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복강경하 난소종괴제거술을 받는 부인과 환자에서 Sevoflurane을 사용한 균형마취시 Remifentanil과 Fentanyl이 술후 구역 구토와 통증에 미치는 영향

Other Titles
 The Effect of Fentanyl and Remifentanil on Postoperative Nausea and Vomiting, and Pain after Gynecologic Laparoscopic Ovarian Cyst Enucleation by Balanced Anesthesia with Sevoflurane 
Authors
 이우경  ;  김용범  ;  최승호  ;  채영근  ;  홍남근  ;  김종훈 
Citation
 KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.50(4) : 390-395, 2006 
Journal Title
 KOREAN JOURNAL OF ANESTHESIOLOGY 
ISSN
 2005-6419 
Issue Date
2006
Keywords
fentanyl ; nausea and vomiting ; pain ; remifentanil
Abstract
BACKGROUND: Opioids are known to increase the incidence of postoperative nausea and vomiting (PONV). Remifentanil is an ultrashort-acting opioid with a potent analgesic effect and is useful for rapid emergence. This study compared the effect of remifentanil on the incidence and severity of PONV and postoperative pain with that of fentanyl in patients undergoing laparoscopic surgery, which is normally associated with a high incidence of PONV. METHODS: Forty-four adult female patients, who were scheduled for laparoscopic ovarian cyst enucleation, were randomly assigned to either the remifentanil or fentanyl group. Anesthesia was induced with propofol after injecting fentanyl 2 µg/kg or remifentnail 1 µg/kg and was maintained with sevoflurane. Remifentanil and fentanyl was infused continuously in the range of 0.2-0.5 µg/kg/min and 0.03-0.05 µg/kg/min, respectively. Ketorolac 0.5 mg/kg was injected 30 min before the end of surgery. The incidence and severity of PONV and pain were recorded upon arrival at the recovery room and 2, 6, 12 and 24 hours thereafter. RESULTS: The incidence and severity of PONV and pain were significantly higher in the remifentanil group upon arrival at the recovery room than in the fentanyl group. The incidence and severity of PONV and pain at the other measurement times were similar. CONCLUSIONS: Despite the ultrashort action duration of the remifentanil, the incidence and severity of PONV and postoperative pain immediately after awakening was higher in the remifentanil group undergoing laparoscopic ovarian cyst enucleation than in the fentanyl group. However, there were no significant differences after two hours in the recovery phase.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Hoon(김종훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109803
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