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Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast

Authors
 Hee Jung Kim  ;  Chan-il Park  ;  Byeong Woo Park  ;  Hy-de Lee  ;  Woo Hee Jung 
Citation
 YONSEI MEDICAL JOURNAL, Vol.47(3) : 333-342, 2006 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2006
MeSH
Breast Neoplasms/genetics ; Breast Neoplasms/physiopathology* ; Carcinoma in Situ/genetics ; Carcinoma in Situ/physiopathology* ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Ductal, Breast/physiopathology* ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinases/genetics* ; Matrix Metalloproteinases, Membrane-Associated ; RNA, Messenger/metabolism ; Tissue Inhibitor of Metalloproteinase-2/genetics
Keywords
Carcinoma ; ductal ; breast ; MT1-MMP ; MMP2 ; MMP9 ; TIMP2 ; prognosis
Abstract
We investigated the expression of membrane type-1 (MT1)-MMP, MMP2, MMP9 and TIMP2 mRNAs and their roles in ductal carcinoma in situ (DCIS) and T1 and T2 invasive ductal carcinoma of the breast. We further compared these two types of carcinomas for differences in microvessel density, and expression of angiogenic factors and CD44std. MT1-MMP, MMP2, MMP9 and TIMP2 mRNA were expressed in both DCIS and invasive ductal carcinomas. Expression rates of MT1-MMP, MMP2, MMP9 and TIMP2 mRNAs were not statistically different between DCIS and invasive ductal carcinomas, nor did they differ statistically when grouped by tumor size, histologic grade or nuclear grade of invasive ductal carcinoma. Microvessel density and expression of VEGF and TGF-β1 were not statistically different between DCIS and invasive ductal carcinoma. CD44std expression was significantly increased in DCIS compared to invasive ductal carcinoma (p < 0.05) and it was also significantly increased in lower clinical stage, histologic grade and nuclear grade of invasive ductal carcinoma (p < 0.05). Axillary node metastasis was significantly correlated with MT1-MMP mRNA, VEGF and TGF-β1 expression (p < 0.05) and MT1-MMP mRNA was positively correlated with VEGF expression and TIMP2 mRNA (p < 0.05). In summary, patterns of MMP mRNA expression in DCIS and invasive ductal carcinoma suggest that the invasive potential of breast carcinoma is already achieved before morphologically overt invasive growth is observed. As MT1-MMP mRNA expression is significantly correlated with axillary nodal metastasis, it may be useful as a prognostic indicator of invasive ductal carcinoma. Considering the positive correlation of MT1-MMP mRNA and TIMP2mRNA expression, our finding supports a role for TIMP2 in tumor growth, as well as the utility of CD44std as a prognostic indicator of breast cancer.
Files in This Item:
T200600861.pdf Download
DOI
10.3349/ymj.2006.47.3.333
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Chan Il(박찬일)
Lee, Hy De(이희대)
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109802
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