Cited 44 times in
Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia
DC Field | Value | Language |
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dc.contributor.author | 이운규 | - |
dc.date.accessioned | 2015-06-10T12:25:56Z | - |
dc.date.available | 2015-06-10T12:25:56Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109790 | - |
dc.description.abstract | Chromosomal abnormalities are implicated as important markers for the pathogenesis in patients with schizophrenia. In this study, with using bacterial artificial chromosome (BAC) array-based comparative genomic hybridization (CGH), we analyzed DNA copy-number changes among 30 patients with schizophrenia. The most frequent changes were partial gain of Xq23 (52%) and loss of 3q13.12 (32%). Other frequent gains were found in: 1p, 6q, 10p, 11p, 11q, 14p, and 15q regions, and frequent losses were found in: 2p, 9q, 10q, 14q, 20q, and 22q regions. The set of abnormal regions was confirmed by real-time PCR (9q12, 9q34.2, 11p15.4, 14q32.33, 15q15.1, 22q11.21, and Xq23). All real-time PCR results were consistent with the array-CGH results. Therefore, it is suggested that array-CGH and real-time PCR analysis could be used as powerful tools in screening for schizophrenia-related genes. Our results might be useful for further exploration of candidate genomic regions in the pathogenesis of schizophrenia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 531~539 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Chromosome Aberrations/statistics & numerical data* | - |
dc.subject.MESH | Chromosome Mapping/methods* | - |
dc.subject.MESH | DNA Mutational Analysis/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease/epidemiology | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization/methods* | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis/methods* | - |
dc.subject.MESH | Schizophrenia/epidemiology* | - |
dc.subject.MESH | Schizophrenia/genetics* | - |
dc.title | Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Ho Jin Moon | - |
dc.contributor.googleauthor | Sung-Vin Yim | - |
dc.contributor.googleauthor | Woon Kyu Lee | - |
dc.contributor.googleauthor | Yang-Whan Jeon | - |
dc.contributor.googleauthor | Young Hoon Kim | - |
dc.contributor.googleauthor | Young Jin Ko | - |
dc.contributor.googleauthor | Kwang-Soo Lee | - |
dc.contributor.googleauthor | Kweon-Haeng Lee | - |
dc.contributor.googleauthor | Sang-Ick Han | - |
dc.contributor.googleauthor | Hyoung Kyun Rha | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.03.156 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02996 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 16630559 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X06007091 | - |
dc.subject.keyword | Schizophrenia | - |
dc.subject.keyword | Chromosomal aberration | - |
dc.subject.keyword | Array-CGHReal-time PCR | - |
dc.subject.keyword | HTR2C | - |
dc.contributor.alternativeName | Lee, Woon Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Woon Kyu | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 344 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 531 | - |
dc.citation.endPage | 539 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.344(2) : 531-539, 2006 | - |
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