Cited 39 times in
Towards an immunodiagnostic test for leprosy
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-06-10T12:25:14Z | - |
dc.date.available | 2015-06-10T12:25:14Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1286-4579 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109769 | - |
dc.description.abstract | In addition to multidrug therapy, elimination of leprosy requires improved diagnostic methods. Using a comparative genomics approach, 17 potential protein antigens (MLP) that are restricted to Mycobacterium leprae, or of limited distribution, were produced and tested for antigen-specific immune responses on leprosy patients, healthy contacts of leprosy patients, and tuberculosis patients in Mali and Bangladesh, as well as on non-endemic controls. T-cell antigenicity of MLP was confirmed by IFN-γ production in whole-blood assays with the highest responses observed in paucibacillary leprosy patients and healthy contacts. Four MLP behaved well in both countries and induced significantly different responses between the study groups. Peptides carrying T cell epitopes from one of the antigens gave promising results in restimulation assays in mice and immune responses were not influenced by prior exposure to BCG or environmental mycobacteria. This study provides the immunological framework for the development of a specific, peptide-based immunodiagnostic test for leprosy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2270~2276 | - |
dc.relation.isPartOf | MICROBES AND INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Bacterial/biosynthesis | - |
dc.subject.MESH | Antigens, Bacterial/immunology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunologic Tests/methods* | - |
dc.subject.MESH | Interferon-gamma/biosynthesis | - |
dc.subject.MESH | Leprosy/diagnosis* | - |
dc.subject.MESH | Leprosy/immunology | - |
dc.subject.MESH | Leukocytes, Mononuclear/immunology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Mycobacterium leprae/immunology* | - |
dc.subject.MESH | Mycobacterium leprae/isolation & purification | - |
dc.subject.MESH | Peptides/immunology | - |
dc.subject.MESH | T-Lymphocytes/immunology | - |
dc.title | Towards an immunodiagnostic test for leprosy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Romulo Aráoz | - |
dc.contributor.googleauthor | Nadine Honoré | - |
dc.contributor.googleauthor | Sayera Banu | - |
dc.contributor.googleauthor | Caroline Demangel | - |
dc.contributor.googleauthor | Yakouba Cissoko | - |
dc.contributor.googleauthor | Charles Arama | - |
dc.contributor.googleauthor | Mohammad Khaja Mafij Uddin | - |
dc.contributor.googleauthor | S.K. Abdul Hadi | - |
dc.contributor.googleauthor | Marc Monot | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Baohong Ji | - |
dc.contributor.googleauthor | Patrick J. Brennan | - |
dc.contributor.googleauthor | Samba Sow | - |
dc.contributor.googleauthor | Stewart T. Cole | - |
dc.identifier.doi | 10.1016/j.micinf.2006.04.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J02228 | - |
dc.identifier.eissn | 1769-714X | - |
dc.identifier.pmid | 16797206 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1286457906001638 | - |
dc.subject.keyword | Comparative genomics | - |
dc.subject.keyword | Comparative proteomics | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | Leprosy immunodiagnosis | - |
dc.subject.keyword | Mycobacterium leprae | - |
dc.subject.keyword | Phenolic glycolipid-1 | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2270 | - |
dc.citation.endPage | 2276 | - |
dc.identifier.bibliographicCitation | MICROBES AND INFECTION, Vol.8(8) : 2270-2276, 2006 | - |
dc.identifier.rimsid | 53406 | - |
dc.type.rims | ART | - |
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