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Experiences with Nonfunctioning Neuroendocrine Neoplasms of the Pancreas

Authors
 Kang C.M.  ;  Kim K.S.  ;  Choi J.S.  ;  Lee W.J.  ;  Kim B.R. 
Citation
 DIGESTIVE SURGERY, Vol.22(6) : 453-458, 2005 
Journal Title
DIGESTIVE SURGERY
ISSN
 0253-4886 
Issue Date
2005
MeSH
Adult ; Aged ; Carcinoma, Islet Cell/mortality ; Carcinoma, Islet Cell/pathology ; Carcinoma, Islet Cell/physiopathology ; Carcinoma, Islet Cell/surgery* ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/physiopathology ; Pancreatic Neoplasms/surgery* ; Retrospective Studies ; Survival Rate
Abstract
Aim: We present our experiences in the treatment of nonfunctioning neuroendocrine neoplasms of the pancreas to define the natural history and to suggest proper management.
Method: From August 1993 to June 2005, the medical records of 19 patients with the diagnosis of nonfunctioning neuroendocrine (islet cell) neoplasms of the pancreas were retrospectively reviewed with respect to patient characteristics, characteristics of neoplasms, surgical procedures, and long-term outcomes in the Yonsei University Medical Center, Seoul, Korea.
Results: The median age of the patients (10 males and 9 females) was 51 years. Abdominal pain and discomfort (58%) were the most frequent symptoms. Tumors with a median size of 3.5 cm were noted in the head of the pancreas in 9 patients and in the body or in the tail of the pancreas in 10 patients. Thirteen patients (68%) had neoplasms with malignant features. Twelve patients (63%) underwent surgical resection, and curative resection was performed in 10 patients (53%). Unresectable neoplasms (p = 0.0055), distant metastases (p = 0.0124), and macroinvasion to adjacent organs (p = 0.024) had significantly adverse effects on the mean survival. Neither palliative surgery nor adjuvant chemoradiation therapy seemed to be effective.
Conclusions: Early detection of nonfunctioning neuroendocrine neoplasms of the pancreas is important, and curative resection should be attempted for a good prognosis.
Full Text
http://www.karger.com/Article/FullText/92011
DOI
10.1159/000092011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Byong Ro(김병로)
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Choi, Jin Sub(최진섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109768
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