212 220

Cited 31 times in

Growth inhibition and apoptosis by (−)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells

Authors
 Young Chang Lim  ;  Seong-Ho Lee  ;  Mee Hyun Song  ;  Kiyoshi Yamaguchi  ;  Joo-Heon Yoon  ;  Eun Chang Choi  ;  Seung Joon Baek 
Citation
 EUROPEAN JOURNAL OF CANCER, Vol.42(18) : 3260-3266, 2006 
Journal Title
 EUROPEAN JOURNAL OF CANCER 
ISSN
 0959-8049 
Issue Date
2006
MeSH
Antineoplastic Agents/therapeutic use* ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology* ; Catechin/analogs & derivatives* ; Catechin/therapeutic use ; Cell Line, Tumor ; Cyclin D1/metabolism* ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/metabolism ; Cytokines/metabolism ; Flavonoids/pharmacology ; Flow Cytometry ; Growth Differentiation Factor 15 ; Growth Inhibitors/therapeutic use* ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology* ; Humans ; Neoplasm Proteins/metabolism* ; Phenols/pharmacology ; Polyphenols
Keywords
ECG ; Cyclin D1 ; Apoptosis ; HNSCC ; β-Catenin ; Chemoprevention
Abstract
In recent studies, green tea components have been shown to induce cell growth arrest and apoptosis in head and neck squamous cell carcinoma (HNSCC) cells. In this report, we have investigated the effects of epicatechin gallate (ECG), one of the catechins in green tea, on anti-cancer activity in vitro. We found that cyclin D1 was highly expressed in HNSCC cells, and ECG suppressed 90% of cyclin D1 expression in SCC7 cells. We have also evaluated the effect of ECG on cell growth and apoptosis, showing that ECG (50 μM) exhibited a significant inhibition (50%) on the growth of SCC7 cells via G1 cell cycle arrest. ECG suppressed cyclin D1 in SCC7 cells in a dose- and time-dependent manner, and the suppression of the β-catenin pathway by ECG is one of the mechanism to facilitate ECG-induced cell growth arrest. These results suggest that ECG has a potential usage as a chemopreventive agent in HNSCC.
Files in This Item:
T200600572.pdf Download
DOI
10.1016/j.ejca.2006.07.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Joo Heon(윤주헌)
Choi, Eun Chang(최은창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109453
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse