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DA-9601, Artemisia Asiatica Herbal Extract, Ameliorates Airway Inflammation of Allergic Asthma in Mice
DC Field | Value | Language |
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dc.contributor.author | 이봉기 | - |
dc.date.accessioned | 2015-06-10T12:10:18Z | - |
dc.date.available | 2015-06-10T12:10:18Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109318 | - |
dc.description.abstract | We previously reported that DA-9601, ethanol herbal extract of Artemisia asiatica, inhibited histamine and leukotriene releases in guinea pig lung mast cells activated with specific antigen/antibody reaction. This study aimed to evaluate the inhibitory effect of DA-9601 on the OVA-induced airway inflammation in allergic asthma mouse model. BALB/c mice were sensitized and challenged with OVA. DA-9601 was administered orally 1 h before every local OVA-challenge. OVA-specific serum IgE was measured by ELISA, recruitment of inflammatory cells in BAL fluids and lung tissues by Diff-Quik and H&E staining, respectively, the expressions of CD40, CD40L and VCAM-1 by immunohistochemistry, goblet cell hyperplasia by PAS staining, activities of MMPs by gelatin zymography, expressions of mRNA and proteins of cytokines by RT-PCR and ELISA, activities of MAP kinases by western blot, and activity of NF-KappaB by EMSA. DA-9601 reduced IgE level, recruitment of inflammatory cells into the BAL fluid and lung tissues, expressions of CD40, CD40L and VCAM-1 molecules, goblet cell hyperplasia, MMPs activity, expressions of mRNA and productions of various cytokines, activities of MAP kinases and NK-KappaB increased from OVA-challenged mice. These data suggest that DA-9601 may be developed as a clinical therapeutic agent in allergic diseases due to suppressing the airway allergic inflammation via regulation of various cellular molecules expressed by MAP kinases/NF-KappaB pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 104~112 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Asthmatic Agents/administration & dosage | - |
dc.subject.MESH | Anti-Asthmatic Agents/pharmacology* | - |
dc.subject.MESH | Anti-Inflammatory Agents/administration & dosage | - |
dc.subject.MESH | Anti-Inflammatory Agents/pharmacology* | - |
dc.subject.MESH | Artemisia/chemistry* | - |
dc.subject.MESH | Asthma/chemically induced | - |
dc.subject.MESH | Asthma/drug therapy* | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/cytology | - |
dc.subject.MESH | CD40 Antigens/biosynthesis | - |
dc.subject.MESH | CD40 Ligand/biosynthesis | - |
dc.subject.MESH | Cytokines/biosynthesis | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/biosynthesis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Lung/metabolism | - |
dc.subject.MESH | Lung/pathology | - |
dc.subject.MESH | MAP Kinase Kinase 4/biosynthesis | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | NF-kappa B/biosynthesis | - |
dc.subject.MESH | Ovalbumin | - |
dc.subject.MESH | Plant Extracts/administration & dosage | - |
dc.subject.MESH | Plant Extracts/pharmacology* | - |
dc.subject.MESH | Vascular Cell Adhesion Molecule-1/biosynthesis | - |
dc.title | DA-9601, Artemisia Asiatica Herbal Extract, Ameliorates Airway Inflammation of Allergic Asthma in Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Dae Yong Kim | - |
dc.contributor.googleauthor | Yun Song Lee | - |
dc.contributor.googleauthor | Bong Ki Lee | - |
dc.contributor.googleauthor | Kyung-Hoon Lee | - |
dc.contributor.googleauthor | Jai Youl Ro | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02806 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 16951557 | - |
dc.subject.keyword | Allergic Asthma | - |
dc.subject.keyword | CD40 | - |
dc.subject.keyword | CD40L | - |
dc.subject.keyword | Goblet Cells | - |
dc.subject.keyword | IgE | - |
dc.subject.keyword | MAP Kinases | - |
dc.subject.keyword | Matrix Metalloproteinases (MMPs) | - |
dc.subject.keyword | NF-kB | - |
dc.subject.keyword | VCAM-1 | - |
dc.contributor.alternativeName | Lee, Bong Ki | - |
dc.contributor.affiliatedAuthor | Lee, Bong Ki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 104 | - |
dc.citation.endPage | 112 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.22(1) : 104-112, 2006 | - |
dc.identifier.rimsid | 52275 | - |
dc.type.rims | ART | - |
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