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제2형 당뇨병환자에서 Pioglitazone이 뇌혈류 개선에 미치는 영향

Other Titles
 Effects of Pioglitazone on Cerebral Hemodynamics in Patients of Type 2 Diabetes 
Authors
 박종숙  ;  이유정  ;  김철식  ;  김혜진  ;  박진아  ;  안철우  ;  이경열  ;  김형진  ;  원영준  ;  하헌주  ;  곽혜선  ;  차봉수  ;  임승길  ;  김경래  ;  이현철 
Citation
 Journal of Korean Diabetes Association (당뇨병), Vol.30(2) : 96-103, 2006 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
ISSN
 2233-6079 
Issue Date
2006
Keywords
IMT (intima-media thickness) ; PI (pulsatility index) ; Pioglitazone ; Type 2 diabetes
Abstract
Background: Atherosclerosis is one of the major causes of morbidity and mortality in patients with type 2 diabetes and pioglitazone has been reported to have antiatherogenic effect. The aim of this study was to investigate whether pioglitazone affects carotid intima-media thickness (IMT) and pulsatility index (PI) in type 2 diabetic patients. Methods: A total of 40 type 2 diabetic patients were included and divided into two groups: the pioglitazone-treated group (pioglitazone 15 mg/day with gliclazide 80~320 mg/day for 12 weeks) (n = 20) and control group (gliclazide 80~320 mg/day for 12 weeks) (n = 20). The changes in lipid profile, insulin resistance, IMT, and PI were monitored to determine that pioglitazone improves cerebrovascular blood flow. Results: The pioglitazone treatment significantly increased HDL-C, reduced triglyceride, insulin resistance and PI. IMT tended to decrease but the change was not significant. This study revealed that treatment with pioglitazone was associated with the improvement of cerebrovascular blood flow. Conclusion: Pioglitazone appears to be effective for the improvement of cerebrovascular blood flow in type 2 diabetic patients.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109265
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