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한국인 제2형 당뇨병 환자에서 렙틴 농도와 작고 밀집한 저밀도 지단백 콜레스테롤 농도와의 관계

Other Titles
 The Relationship between the Leptin Concentration and the Small Dense Low Density Lipoprotein Cholesterol Concentration in Korean Type 2 Diabetic Patients 
Authors
 심완섭  ;  김혜진  ;  강은석  ;  이유미  ;  안철우  ;  임승길  ;  이현철  ;  차봉수 
Citation
 Journal of Korea Society of Endocrinology (대한내분비학회지), Vol.21(4) : 319-327, 2006 
Journal Title
 Journal of Korea Society of Endocrinology (대한내분비학회지) 
ISSN
 1015-6380 
Issue Date
2006
Keywords
Leptin ; Precipitation method ; Small dense LDL, Type 2 diabetes mellitus
Abstract
Background: Leptin has been suggested as a possible cause of atherosclerotic disease. The small dense low-density lipoprotein cholesterol (LDL-C) has also been regarded as a new surrogate marker in atherosclerotic disease. The aim of this study was to evaluate the relationship between the leptin concentration and the small dense LDL-C concentration in Korean type 2 diabetic patients. Methods: One hundred-ninety one type 2 diabetic patients, who did not use any medication that could affect the concentration of lipid such as statin, fibrate, thiazolidinediones and corticosteroid, were enrolled in this study. We analyzed the relationship between leptin, the small dense LDL-C and the other metabolic parameters. Results: The small dense LDL-C concentrations were higher in the group with the highest tertile of the leptin value, both in males and females than those patients in the group with the lowest tertile of the leptin value. The small dense LDL-C concentrations were also higher in the group with the highest tertile of leptin divided by the BMI value both in males and females than those patients in the group with the lowest tertile of the leptin value. The leptin concentration was positively correlated with the small dense LDL-C, total cholesterol, triglyceride, LDL-C, insulin and HOMAIR values after adjusting for age, gender and BMI. Conclusion: The association between leptin and small dense LDL-C could be a factor that explains the association between leptin and cardiovascular disease.
Files in This Item:
T200600413.pdf Download
DOI
10.3803/jkes.2006.21.4.319
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109262
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