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제2형 당뇨병환자에서 장기간의 피오글리타존 투여에 따른 임상적 관찰

Other Titles
 Long-term Effect of Pioglitazone Treatment in Patients with Type 2 Diabetes 
Authors
 문재훈  ;  김혜진  ;  김수경  ;  심완섭  ;  강은석  ;  이유미  ;  안철우  ;  임승길  ;  김경래  ;  이현철  ;  차봉수 
Citation
 Journal of Korean Diabetes Association (당뇨병), Vol.30(4) : 264-276, 2006 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
ISSN
 2233-6079 
Issue Date
2006
Keywords
Anthropometrics ; Pioglitazone ; Thiazolidinedione
Abstract
Background: Type 2 diabetes is characterized by impaired insulin secretion and/or insulin resistance. Thiazolidinediones have been shown to ameliorate insulin resistance. The purpose of the present study was to evaluate the long term serial effect of pioglitazone on anthropometrics and metabolic parameters in Korean type 2 diabetes patients. Methods: One hundred thirteen type 2 diabetes patients (male, 67; female, 46; mean age, 49.1 ± 10.8 years) were evaluated before and after 3 months, 6 months and 12 months of treatment with pioglitazone (Actos(TM), 15 mg/day). Anthropometric parameters and metabolic variables were measured. Results: Body weight and body mass index (BMI) were increased in 3 months after pioglitazone treatment (body weight, 68.8 ± 12.2 vs 69.8 ± 11.9 kg, P < 0.01) without further increase. In women, body weight and BMI tended to increase more (body weight change after 3 months, 0.6 ± 1.7 kg vs 1.6 ± 1.7 kg, P < 0.01) and longer (3 months vs 6 months) than in men. Fasting plasma glucose (FPG) and HbA1c were decreased in 3 months after pioglitazone treatment (FPG, 7.97 ± 2.29 vs 6.94 ± 2.01 mmol/L, P < 0.01; HbA1c, 7.7 ± 1.5 vs 7.0 ± 1.1%, P < 0.01). Hypoglycemic effect of pioglitazone was prominent in women than in men (FPG change after 12 months, -1.80 ± 2.54 vs -0.09 ± 1.72 mmol/L, P < 0.001; HbA1c change after 12 months, -0.9 ± 1.3 vs -0.4 ± 1.1%, P < 0.05). Serum high-density lipoprotein cholesterol was increased after 3 months of pioglitazone treatment (1.16 ± 0.24 vs 1.31 ± 0.28 mmol/L, P < 0.01) without return until the end of this study. Serum triglycerides level decreased at 3 months (basal vs 3 months, 2.29 ± 1.86 vs 1.88 ± 1.21 mmol/L, P < 0.01) and 6 months (basal vs 6 months, 2.29 ± 1.86 vs 1.97 ± 1.40 mmol/L, P< 0.05) of pioglitazone treatment, but returned to basal level at 12 months. Liver enzyme, especially serum alanine transferase level decreased after 3 months of pioglitazone treatment (30.8 ± 23.7 vs 24.5 ± 18.5 IU/L, P < 0.01) without return until the end of this study. Hypoglycemic effect of pioglitazone was associated with basal BMI, fat contents and serum leptin level. Conclusion: Korean type 2 diabetes patients with pioglitazone use showed favorable metabolic effect for glycemic control, lipid metabolism and liverfunction, but pioglitazone induced body weight increase may be limited.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109261
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