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갑상선 유두암을 동반한 제1형 다발성 내분비 선종증 1예

Other Titles
 A Case of Multiple Endocrine Neoplasia Type 1 with Papillary Thyroid Carcinoma 
Authors
 김혜진  ;  김철식  ;  제현철  ;  박진아  ;  박종숙  ;  공지현  ;  강은석  ;  안철우  ;  차봉수  ;  임승길  ;  김경래  ;  이현철  ;  장항석  ;  홍순원 
Citation
 Journal of Korea Society of Endocrinology (대한내분비학회지), Vol.21(1) : 79-84, 2006 
Journal Title
 Journal of Korea Society of Endocrinology (대한내분비학회지) 
ISSN
 1015-6380 
Issue Date
2006
Keywords
MEN 1 ; Papillary thyroid carcinoma ; Prolactinoma ; Gastrinoma ; Parathyroid hyperplasia
Abstract
This is the first report of papillary thyroid carcinoma combined with multiple endocrine neoplasia type 1 (MEN 1). It is an hereditary syndrome characterized by neoplastic disorders such as pituitary adenoma, parathyroid adenoma or hyperplasia and pancreatic neuroendocrine tumor, such as gastrinoma just like in our case. But sometimes pheochromocytoma, mucosal ganglioneuromas, lipoma, forgut carcinoid and thyroid disease could be accompany the disease, but coincidental papillary thyroid carcinoma was never reported before in Korea. Herein we represent a 39-year-old woman who manifested typical features of MEN 1 with coincidental papillary thyroid carcinoma. Despite with definite family history of MEN 1, her genetic analysis of DNA had not found any germline mutation in MEN 1 gene. Unidentified culprit gene unable further genetic study of finding LOH (loss of heterogeneity) in 11q13, the possible explanation of papillary thyroid carcinoma as a new component of MEN 1. As we have experienced a case of MEN 1 combined with papillary thyroid carcinoma, we report it with the review of literature.
Files in This Item:
T200600411.pdf Download
DOI
10.3803/jkes.2006.21.1.79
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109259
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