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The clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the differential diagnosis, staging, and response evaluation after concurrent chemoradiotherapy for pancreatic cancer

Authors
 Seungmin Bang  ;  Hye Won Chung  ;  Seung Woo Park  ;  Jae Bock Chung  ;  Mijin Yun  ;  Jong Doo Lee  ;  Si Young Song 
Citation
 JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.40(10) : 923-929, 2006 
Journal Title
 JOURNAL OF CLINICAL GASTROENTEROLOGY 
ISSN
 0192-0790 
Issue Date
2006
MeSH
Aged ; Antineoplastic Agents/therapeutic use* ; Biomarkers, Tumor/blood ; CA-19-9 Antigen/blood ; Carcinoma, Pancreatic Ductal/diagnostic imaging* ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/pathology* ; Carcinoma, Pancreatic Ductal/radiotherapy ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Diagnosis, Differential ; Diagnostic Errors ; Female ; Fluorodeoxyglucose F18* ; Follow-Up Studies ; Humans ; Korea ; Male ; Middle Aged ; Neoplasm Staging ; Pancreatic Neoplasms/diagnostic imaging* ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology* ; Pancreatic Neoplasms/radiotherapy ; Pancreatitis, Chronic/diagnostic imaging ; Pancreatitis, Chronic/pathology ; Positron-Emission Tomography* ; Radiopharmaceuticals* ; Radiotherapy, Adjuvant ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Treatment Outcome
Keywords
pancreatic cancer ; 18FDG-PET ; CT scan ; chronic pancreatitis ; differential diagnosis
Abstract
GOALS: The aims of this study were to determine the clinical use of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the differential diagnosis of patients with suspected pancreatic cancer and in the determination of tumor response after concurrent chemoradiotherapy for pancreatic cancer. BACKGROUND: Despite advances in diagnostic tools for pancreatic cancer, it is difficult to differentiate pancreatic cancer from mass-forming pancreatitis. Even with current imaging modalities, it is also difficult to assess tumor response to therapeutic intervention. STUDY: One hundred two patients with suspected pancreatic cancer were selected for this study. Dynamic computerized tomography (CT) scan and FDG-PET were used sequentially to diagnose pancreatic cancer. After diagnostic confirmation their diagnostic yields were compared. We also evaluated the treatment response in 15 patients who underwent chemoradiation therapy with dynamic CT scan and FDG-PET and compared their results. RESULTS: In 93 out of 102 patients, pancreatic cancer was confirmed. FDG-PET showed higher diagnostic accuracy than CT scan (95.1% vs. 76.5%). FDG-PET was also superior to CT in the detection of liver metastasis. FDG-PET detected treatment response in 5 out of 15 cases after chemoradiation therapy, whereas CT could not detect any treatment response. Comparing responder and nonresponder, FDG-PET was able to predict significantly different prognosis (399 vs. 233 d, P<0.05). CONCLUSIONS: FDG-PET is a very useful tool in diagnosing pancreatic cancer. FDG-PET may be also used as an adjunct for determining the treatment modality of pancreatic cancer and evaluating tumor response to chemoradiation therapy.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-200611000-00010&LSLINK=80&D=ovft
DOI
10.1097/01.mcg.0000225672.68852.05
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jong Doo(이종두)
Chung, Jae Bock(정재복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109257
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