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건강한 폐경기 여성에서 호르몬 대체요법이 경동맥 내중막두께에 미치는 영

Other Titles
 The Effect of Hormone Replacement Therapy on Carotid Intima-Media Thickness in Healthy Postmenopausal Women 
 신장열  ;  차봉수  ;  정춘희  ;  심원흠  ;  이현철 
 Journal of Korea Society of Endocrinology (대한내분비학회지), Vol.21(1) : 14-21, 2006 
Journal Title
 Journal of Korea Society of Endocrinology (대한내분비학회지) 
Issue Date
Atherosclerosis ; Cardiovascular disease ; Hormone replacement therapy ; Intima media thickness ; Postmenopause
Background: Cardiovascular disease is the leading cause of death in postmenopausal women. The use of hormone replacement therapy (HRT) preventing for cardiovascular disease in postmenopausal women remains controversial. We investigated the effect of HRT on carotid intima-media thickness (IMT) according to the HRT duration in healthy postmenopausal women. Methods: One hundred and twenty postmenopausal women (mean age: 55.4 ± 3.3 years) were classified into never users, short-term, and long-term users according to the HRT duration. Carotid IMT was measured, and the clinical and biochemical cardiovascular risk factors were examined. Results: The mean IMT was significantly thinner in the long-term users than that in the never users (0.62 ± 0.11 vs. 0.71 ± 0.14 mm, P < 0.01). Also, the maximal IMT was significantly thinner in the short-term and the long-term users. However, there is no significant difference in the mean and maximal IMTs between the estrogen alone and estrogen plus progestins used group. The period exposed to menopause was significantly shorter in the long-term users than that in the never users (1.8 ± 2.3 vs. 4.3 ± 3.3 years, P < 0.001). Conclusion: Our findings suggest that if HRT is initiated during early postmenopausal period before the onset of atherosclerosis, HRT may have a beneficial effect on the prevention of carotid atherosclerosis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shim, Won Heum(심원흠)
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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