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Normative values of carotid artery intima-media thickness in healthy Korean adults and estimation of macrovascular diseases relative risk using this data in type 2 diabetes patients

Authors
 Chul Sik Kim  ;  Hyeong Jin Kim  ;  Young Jun Won  ;  Dae Jung Kim  ;  Eun Seok Kang  ;  Chul Woo Ahn  ;  Bong Soo Cha  ;  Sung Kil Lim  ;  Kyung Rae Kim  ;  Hyun Chul Lee  ;  Kap Bum Huh 
Citation
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.72(2) : 183-189, 2006 
Journal Title
 DIABETES RESEARCH AND CLINICAL PRACTICE 
ISSN
 0168-8227 
Issue Date
2006
MeSH
Adult ; Age Factors ; Aged ; Arterial Occlusive Diseases/etiology ; Cardiovascular Diseases/etiology* ; Carotid Artery, Common/anatomy & histology* ; Carotid Artery, Common/diagnostic imaging ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/pathology* ; Female ; Humans ; Korea ; Male ; Middle Aged ; Myocardial Ischemia/etiology ; Peripheral Vascular Diseases/etiology ; Reference Values ; Risk Factors ; Sex Factors ; Stroke/etiology ; Tunica Intima/anatomy & histology* ; Tunica Intima/diagnostic imaging ; Tunica Media/anatomy & histology* ; Tunica Media/diagnostic imaging ; Ultrasonography
Keywords
Intima-media thickness ; Type 2 diabetes mellitus ; Macrovascular disease ; Relative risk
Abstract
The objectives of this study were to determine normative values of carotid intima-media thickness (IMT) in healthy Korean subjects and to use these values to estimate the relative risk of macrovascular diseases in patients with type 2 diabetes mellitus (T2DM). High-resolution B-mode ultrasonography was performed in 1229 healthy subjects and 830 T2DM patients. Height, weight, blood pressure, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and fasting insulin level were measured. Subjects were classified as healthy subjects; T2DM patients without ischemic heart disease (IHD), stroke, and peripheral arterial occlusive diseases (PAOD); T2DM patients with IHD, stroke, or PAOD. IMT was significantly increased as age increased. Patients with T2DM had higher IMTs compared to healthy subjects. Independent risk factors of IMT were age, systolic blood pressure, BMI for healthy subjects, and age, duration of diabetes, LDL-cholesterol for T2DM subjects. According to presence of increased IMT, the relative risks of IHD, stroke, and PAOD in diabetic subjects, were 2.34 (CI; 1.32–4.14), 2.95 (CI; 1.46–5.54), and 3.64 (CI; 1.66–7.40), respectively. This study suggests normative values that can be used as an index for carotid artery IMT of healthy Korean subjects, and that IMT data reflects the risk of macrovascular diseases in T2DM.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168822705004109
DOI
10.1016/j.diabres.2005.10.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109254
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