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Synthesis and characterization of mesoporous Fe/SiO2 for magnetic drug targeting

Authors
 Hyun-Jong Kim  ;  Ji-Eun Ahn  ;  Seungjoo Haam  ;  Yong-Gun Shul  ;  Si-Young Song  ;  Takashi Tatsumi 
Citation
 JOURNAL OF MATERIALS CHEMISTRY , Vol.16(17) : 1617-1621, 2006 
Journal Title
 JOURNAL OF MATERIALS CHEMISTRY 
ISSN
 0959-9428 
Issue Date
2006
Abstract
Mesoporous Fe/SiO2 was synthesized as a carrier for magnetic drug targeting by using the sol–gel route and a chemical reduction method. It was confirmed that metallic iron clusters were formed and retained in the channels of the mesoporous silica by XRD and N2 adsorption. The magnetic properties and stability of mesoporous Fe/SiO2 were characterized by vibrating sample magnetometry and XPS. The oxidation of metallic iron and subsequent reduction of magnetic properties were retarded by the mesoporous silica framework and the surface-formed non-magnetic iron oxide layer. The release of ibuprofen from the mesoporous Fe/SiO2 was described as a diffusion-controlled process (Higuchi relationship). It showed two-step release composed of an initial burst and a slow steady release for 700 hours. This was due to the physical and chemical entrapping of drug in the mesoporous Fe/SiO2 particles. The release rate could be also controlled by surface modification of drug-loaded mesoporous Fe/SiO2 with a biologically compatible polymer such as PCL.
Full Text
http://pubs.rsc.org/en/content/articlelanding/2006/JM/b514433g#!divAbstract
DOI
10.1039/B514433G
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109252
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