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Successful use of cyclosporin A in severe Schönlein–Henoch nephritis resistant to both methylprednisolone pulse and azathioprine

Authors
 Jae Il Shin  ;  Jee Min Park  ;  Jae Seung Lee  ;  Ji Hong Kim  ;  Pyung Kil Kim  ;  Hyeon Joo Jeong 
Citation
 CLINICAL RHEUMATOLOGY, Vol.25(5) : 759-760, 2006 
Journal Title
CLINICAL RHEUMATOLOGY
ISSN
 0770-3198 
Issue Date
2006
MeSH
Azathioprine/therapeutic use* ; Child ; Cyclosporine/therapeutic use* ; Drug Resistance, Multiple ; Glucocorticoids/therapeutic use* ; Humans ; Immunosuppressive Agents/therapeutic use* ; Male ; Methylprednisolone/therapeutic use* ; Nephritis/drug therapy* ; Nephritis/etiology ; Nephritis/pathology ; Pulse Therapy, Drug ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/drug therapy* ; Purpura, Schoenlein-Henoch/pathology ; Remission Induction ; Treatment Outcome
Keywords
Cyclosporin A ; Heavy proteinuria ; Schönlein–Henoch nephritis
Abstract
Schönlein–Henoch nephritis (SHN) usually presents with micro-haematuria or mild proteinuria but can be associated with heavy proteinuria and nephrotic or acute nephritic syndrome. Although the treatment of SHN is still under debate, it has been suggested that cyclosporin A (CsA) may be beneficial in children with severe SHN, as reported by Ronkainen et al. (Pediatr Nephrol 18:1138–1142, 2003) and Someya et al. (Pediatr Int 46:111–113, 2004). However, histological effects of CsA on severe SHN had not been evaluated in their evaluations. We report the successful use of CsA in a male patient with severe SHN with nephrotic-range proteinuria, who failed to respond to methylprednisolone pulse and azathioprine therapy.
Full Text
http://link.springer.com/article/10.1007%2Fs10067-005-0066-4
DOI
10.1007/s10067-005-0066-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hong(김지홍) ORCID logo https://orcid.org/0000-0001-5352-5423
Lee, Jae Seung(이재승)
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/109226
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